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Peutz-Jeghers syndrome and screening for pancreatic cancer

Latchford, A. and Greenhalf, W. and Vitone, L. J. and Neoptolemos, J. P. and Lancaster, Gillian and Phillips, R. K. S. (2006) Peutz-Jeghers syndrome and screening for pancreatic cancer. The British journal of surgery, 93 (12). pp. 1446-1455. ISSN 0007-1323

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Abstract

Background: Cancer risk, including pancreatic, is high in those with Peutz–Jeghers syndrome (PJS). It has been suggested that such patients should undergo screening for pancreatic cancer. Methods: The risk of pancreatic cancer in PJS, pancreatic screening and potential screening strategies were reviewed. Cost-effectiveness was assessed according to American Gastroenterology Association guidelines and a risk stratification model proposed by the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer. Results: The risk of pancreatic cancer is increased in PJS but screening would cost over US $350 000 per life saved. Risk stratification reduces cost by $100 000 and costs fall to $50 000 per life saved if deaths from other forms of cancer are avoided. Conclusion: Screening should be performed only on a research basis to evaluate the benefit and cost-effectiveness in high-risk groups

Item Type: Article
Journal or Publication Title: The British journal of surgery
Subjects: Q Science > QA Mathematics
Departments: Faculty of Science and Technology > Mathematics and Statistics
ID Code: 59932
Deposited By: ep_importer_pure
Deposited On: 12 Nov 2012 11:04
Refereed?: Yes
Published?: Published
Last Modified: 10 Apr 2014 00:18
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/59932

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