Latchford, A. and Greenhalf, W. and Vitone, L. J. and Neoptolemos, J. P. and Lancaster, Gillian and Phillips, R. K. S. (2006) Peutz-Jeghers syndrome and screening for pancreatic cancer. The British journal of surgery, 93 (12). pp. 1446-1455. ISSN 0007-1323Full text not available from this repository.
Background: Cancer risk, including pancreatic, is high in those with Peutz–Jeghers syndrome (PJS). It has been suggested that such patients should undergo screening for pancreatic cancer. Methods: The risk of pancreatic cancer in PJS, pancreatic screening and potential screening strategies were reviewed. Cost-effectiveness was assessed according to American Gastroenterology Association guidelines and a risk stratification model proposed by the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer. Results: The risk of pancreatic cancer is increased in PJS but screening would cost over US $350 000 per life saved. Risk stratification reduces cost by $100 000 and costs fall to $50 000 per life saved if deaths from other forms of cancer are avoided. Conclusion: Screening should be performed only on a research basis to evaluate the benefit and cost-effectiveness in high-risk groups
|Journal or Publication Title:||The British journal of surgery|
|Subjects:||Q Science > QA Mathematics|
|Departments:||Faculty of Science and Technology > Mathematics and Statistics|
|Deposited On:||12 Nov 2012 11:04|
|Last Modified:||20 Nov 2012 16:39|
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