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Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability

Alhamoruni, A. and Wright, Karen and Larvin, M. and O'Sullivan, S. E. (2012) Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability. British Journal of Pharmacology, 165 (8). pp. 2598-610. ISSN 1476-5381

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Abstract

Activation of cannabinoid receptors decreases emesis, inflammation, gastric acid secretion and intestinal motility. The ability to modulate intestinal permeability in inflammation may be important in therapy aimed at maintaining epithelial barrier integrity. The aim of the present study was to determine whether cannabinoids modulate the increased permeability associated with inflammation in vitro.

Item Type: Article
Journal or Publication Title: British Journal of Pharmacology
Additional Information: © 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society.
Uncontrolled Keywords: intestinal permeability ; inflammation ; Caco-2 cells ; cytokines ; transepithelial electrical resistance (TEER) ; endocannabinoid ; cannabinoid CB1 receptor;Δ9-tetrahydrocannabinol and cannabidiol
Subjects: R Medicine > RM Therapeutics. Pharmacology
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 59066
Deposited By: ep_importer_pure
Deposited On: 09 Oct 2012 16:48
Refereed?: Yes
Published?: Published
Last Modified: 06 Aug 2013 11:04
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/59066

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