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Monoterpenoid extract of sage (Salvia lavandulaefolia) with cholinesterase inhibiting properties improves cognitive performance and mood in healthy adults

Kennedy, David O. and Dodd, Fiona L. and Robertson, Bernadette C. and Okello, Edward J. and Reay, Jonathon L. and Scholey, Andrew B. and Haskell, Crystal F. (2011) Monoterpenoid extract of sage (Salvia lavandulaefolia) with cholinesterase inhibiting properties improves cognitive performance and mood in healthy adults. Journal of Psychopharmacology, 25 (8). pp. 1088-1100. ISSN 0269-8811

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Abstract

Extracts of sage (Salvia officinalis/lavandulaefolia) with terpenoid constituents have previously been shown to inhibit cholinesterase and improve cognitive function. The current study combined an in vitro investigation of the cholinesterase inhibitory properties and phytochemical constituents of a S. lavandulaefolia essential oil, with a double-blind, placebo-controlled, balanced crossover study assessing the effects of a single dose on cognitive performance and mood. In this latter investigation 36 healthy participants received capsules containing either 50 µL of the essential oil or placebo on separate occasions, 7 days apart. Cognitive function was assessed using a selection of computerized memory and attention tasks and the Cognitive Demand Battery before the treatment and 1-h and 4-h post-dose. The essential oil was a potent inhibitor of human acetylcholinesterase (AChE) and consisted almost exclusively of monoterpenoids. Oral consumption lead to improved performance of secondary memory and attention tasks, most notably at the 1-h post-dose testing session, and reduced mental fatigue and increased alertness which were more pronounced 4-h post-dose. These results extend previous observations of improved cognitive performance and mood following AChE inhibitory sage extracts and suggest that the ability of well-tolerated terpenoid-containing extracts to beneficially modulate cholinergic function and cognitive performance deserves further attention.

Item Type: Article
Journal or Publication Title: Journal of Psychopharmacology
Uncontrolled Keywords: Acetylcholinesterase ; attention ; memory ; monoterpenoid ; mood ; sage ; salvia ; Salvia lavandulaefolia
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Departments: Faculty of Science and Technology > Psychology
ID Code: 58558
Deposited By: ep_importer_pure
Deposited On: 25 Sep 2012 16:39
Refereed?: Yes
Published?: Published
Last Modified: 31 Mar 2014 10:58
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/58558

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