Taylor, Adam and Boyde, A. and Davidson, J. S. and Jarvis, Jonathan C. and Ranganath, L. R. and Gallagher, J. A. (2012) Identification of trabecular excrescences, novel microanatomical structures, present in bone in osteoarthropathies. European Cells & Materials, 23. pp. 300-309. ISSN 1473-2262Full text not available from this repository.
It is widely held that bone architecture is finely regulated in accordance with homeostatic requirements. Aberrant remodelling (hyperdensification and/or cyst formation in the immediately subchondral region) has previously been described in bone underlying cartilage in arthropathies. The present study examined the trabecular architecture of samples of bone, initially in the severe osteoarthropathy of alkaptonuria, but subsequently in osteoarthritis using a combination of light microscopy, 3D scanning electron microscopy and quantitative backscattered electron scanning electron microscopy. We report an extraordinary and previously unrecognised bone phenotype in both disorders, including novel microanatomical structures. The underlying subchondral trabecular bone contained idiosyncratic architecture. Trabecular surfaces had numerous outgrowths that we have termed "trabecular excrescences", of which three distinct types were recognised. The first type arose from incomplete resorption of branching secondary trabeculae arising from the deposition of immature (woven) bone in prior marrow space. These were characterised by very deeply scalloped surfaces and rugged edges. The second type had arisen in a similar way but been smoothed over by new bone deposition. The third type, which resembled coarse stucco, probably arises from resting surfaces that had been focally reactivated. These were poorly integrated with the prior trabecular wall. We propose that these distinctive microanatomical structures are indicative of abnormal osteoclast/osteoblast modelling in osteoarthropathies, possibly secondary to altered mechanical loading or other aberrant signalling. Identification of the mechanisms underlying the formation of trabecular excrescences will contribute to a better understanding of the role of aberrant bone remodelling in arthropathies and development of new therapeutic strategies.
|Journal or Publication Title:||European Cells & Materials|
|Uncontrolled Keywords:||Bone remodelling ; scanning electron microscopy ; osteoarthritis ; alkaptonuria|
|Departments:||Faculty of Health and Medicine > Medicine|
|Deposited On:||18 Sep 2012 16:08|
|Last Modified:||14 Mar 2014 09:17|
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