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Abnormalities of nonvisually-guided eye movements in Parkinson's Disease

Crawford, Trevor and Henderson, Leslie and Kennard, Christopher (1989) Abnormalities of nonvisually-guided eye movements in Parkinson's Disease. Brain, 112 (6). pp. 1573-1586. ISSN 0006-8950

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Abstract

Rapid eye movements (saccades) were examined in 7 patients with idiopathic Parkinson's disease (PD) and a matched group of normal control subjects. The effect of instructional and stimulus conditions used to elicit saccades was examined using 3 experimental paradigms. Eye movements directly elicited by a novel peripheral target were unimpaired in patients with PD as compared with control subjects. Saccades to a remembered target location, however, were dysmetric in the PD group and showed a characteristic multistepping pattern. The PD impairment was not caused by a loss of information on target location since their final eye position was close to the target at all eccentricities. Peak velocity, duration, and latency did not distinguish between PD patients and controls. These results support the view that for saccades which are not directly elicited by a visual target there is a neural pathway that can be distinguished from structures involved in the generation of visually elicited (or 'reflexive') saccades. The finding that in PD saccades to a remembered target are selectively impaired suggests that structures in the basal ganglia play a crucial role in this alternative pathway.

Item Type: Article
Journal or Publication Title: Brain
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Departments: Faculty of Science and Technology > Psychology
ID Code: 58199
Deposited By: ep_importer_pure
Deposited On: 24 Oct 2012 14:58
Refereed?: Yes
Published?: Published
Last Modified: 10 Apr 2014 00:09
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/58199

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