Elfick, Alistair P. D. and Green, Sarah M. and Krikler, Steve and Unsworth, Anthony (2003) The nature and dissemination of UHMWPE wear debris retrieved from periprosthetic tissue of THR. Journal of Biomedical Materials Research Part A, 65 (1). pp. 95-108. ISSN 1549-3296Full text not available from this repository.
The role of wear debris in provoking joint replacement failure through bone resorption is now supported by much research. This study presents the analysis of 104 tissue samples using laser diffraction wear particle analysis in conjunction with standard histologic methods. The number and volume distributions were correlated to a range of joint and patient parameters. The median particle diameter by number was 0.69 μm. No particles smaller than 0.113 μm were resolved. No variation in terms of particle distribution was found among joint types. The ability of particles to migrate away from their point of origin was found to be inversely proportional to their size. The numbers of particles per gram of tissue found in various regions around the prosthesis varied little. Further, the numbers of particles in tissue samples shown to have a chronic foreign-body reaction was > 1 × 109 particles/gram.
|Journal or Publication Title:||Journal of Biomedical Materials Research Part A|
|Uncontrolled Keywords:||THR ; prosthetic wear debris ; UHMWPE ; explanted ; dissemination|
|Subjects:||T Technology > TA Engineering (General). Civil engineering (General)|
|Departments:||Faculty of Science and Technology > Engineering|
|Deposited On:||16 Oct 2012 14:00|
|Last Modified:||03 Nov 2015 16:26|
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