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Mitochondria, maternal inheritance, and male aging

Camus, M. Florencia and Clancy, David J. and Dowling, Damian K. (2012) Mitochondria, maternal inheritance, and male aging. Current Biology, 22 (18). pp. 1717-1721. ISSN 0960-9822

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Abstract

The maternal transmission of mitochondrial genomes invokes a sex-specific selective sieve, whereby mutations in mitochondrial DNA can only respond to selection acting directly on females [1-3]. In theory, this enables male-harming mutations to accumulate in mitochondrial genomes when these same mutations are neutral, beneficial, or only slightly deleterious in their effects on females [1-3]. Ultimately, this evolutionary process could result in the evolution of male-specific mitochondrial mutation loads; an idea previously termed Mother's Curse [2, 4-6]. Here, we present evidence that the effects of this process are broader than hitherto realized, and that it has resulted in mutation loads affecting patterns of aging in male, but not female Drosophila melanogaster. Furthermore, our results indicate that the mitochondrial mutation loads affecting male aging generally comprise numerous mutations over multiple sites. Our findings thus suggest that males are subject to dramatic consequences that result from the maternal transmission of mitochondrial genomes. They implicate the diminutive mitochondrial genome as a hotspot for mutations that affect sex-specific patterns of aging, thus promoting the idea that a sex-specific selective sieve in mitochondrial genome evolution is a contributing factor to sexual dimorphism in aging, commonly observed across species [7-9].

Item Type: Article
Journal or Publication Title: Current Biology
Additional Information: Copyright © 2012 Elsevier Ltd. All rights reserved.
Subjects: R Medicine > R Medicine (General)
Departments:
ID Code: 57643
Deposited By: ep_importer_pure
Deposited On: 18 Aug 2012 14:14
Refereed?: Yes
Published?: Published
Last Modified: 23 Jul 2014 15:04
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/57643

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