Williamson, D H and Wilson, R J and Bates, P A and McCready, S and Perler, F and Qiang, B U (1985) Nuclear and mitochondrial DNA of the primate malarial parasite Plasmodium knowlesi. Molecular and Biochemical Parasitology, 14 (2). pp. 199-209. ISSN 0166-6851
Full text not available from this repository.Abstract
Restriction analyses and DNA/DNA hybridisation of parasite DNA isolated from monkeys infected with the malarial parasite Plasmodium knowlesi has permitted unambiguous identification of the nuclear DNA of this species. Its (G+C) content, as determined by estimations of buoyant density as well as by direct analysis, is about 38%, essentially indistinguishable from that of its primate laboratory host, and grossly different from that of the major human malaria parasite, P. falciparum, which has a (G+C) content of approx. 19%. In addition, gradient fractionation of total P. knowlesi DNA revealed a minor DNA component (approx. 1% of the total) with a (G+C) content of about 19%. This DNA comprises covalently closed circular molecules which have a contour length about 11.6 microns, carry a small cruciform structure, and are thought to originate in the parasite's mitochondria.
| Item Type: | Article |
|---|---|
| Journal or Publication Title: | Molecular and Biochemical Parasitology |
| Uncontrolled Keywords: | Plasmodium knowlesi ; Malaria ; Nuclear DNA ; Mitochondrial DNAv |
| Subjects: | Q Science > QR Microbiology > QR355 Virology |
| Departments: | Faculty of Health and Medicine > Biomedical & Life Sciences |
| ID Code: | 56299 |
| Deposited By: | ep_importer_pure |
| Deposited On: | 27 Jul 2012 16:14 |
| Refereed?: | Yes |
| Published?: | Published |
| Last Modified: | 27 Jul 2012 16:14 |
| Identification Number: | |
| URI: | http://eprints.lancs.ac.uk/id/eprint/56299 |
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