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Activation of the Abelson tyrosine kinase activity is associated with suppression of apoptosis in hemopoietic cells

Evans, C A and Owen-Lynch, P J and Whetton, A D and Dive, C (1993) Activation of the Abelson tyrosine kinase activity is associated with suppression of apoptosis in hemopoietic cells. Cancer Research, 53 (8). pp. 1735-1738. ISSN 0008-5472

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Abstract

A chromosomal translocation uniquely associated with chronic myeloid leukemia leads to the formation of a chimeric gene, bcr-abl, on the Philadelphia chromosome. The BRC-ABL protein displays an uncontrolled tyrosine kinase activity similar to that seen with the transforming oncogene of the Abelson murine leukemia (ABL) virus (v-abl). An interleukin 3 dependent cell line, IC.DP, has been transfected with a gene encoding a temperature sensitive v-ABL. In the absence of interleukin 3 at the restrictive temperature for ABL tyrosine kinase activity IC.DP cells died via apoptosis. At the permissive temperature ABL tyrosine kinase activity promoted IC.DP cell survival but not proliferation. ABL therefore can specifically suppress apoptosis.

Item Type: Article
Journal or Publication Title: Cancer Research
Subjects: Q Science > QR Microbiology
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 56090
Deposited By: ep_importer_pure
Deposited On: 24 Jul 2012 11:51
Refereed?: Yes
Published?: Published
Last Modified: 09 Apr 2014 23:51
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/56090

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