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Synthetic glycovaccine protects against the bite of leishmania-infected sand flies

Rogers, Matthew E and Sizova, Olga V and Ferguson, Michael A J and Nikolaev, Andrei V and Bates, Paul A (2006) Synthetic glycovaccine protects against the bite of leishmania-infected sand flies. Journal of Infectious Diseases, 194 (4). pp. 512-518. ISSN 0022-1899

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Abstract

Leishmaniasis is a vectorborne disease transmitted to human and other mammalian hosts by sand fly bite. In the present study, we show that immunization with Leishmania mexicana promastigote secretory gel (PSG) or with a chemically defined synthetic glycovaccine containing the glycans found in L. mexicana PSG can provide significant protection against challenge by the bite of infected sand flies. Only the glycan from L. mexicana was protective; those from other species did not protect against L. mexicana infection. Furthermore, neither PSG nor the glycovaccine protected against artificial needle challenge, which is traditionally used in antileishmanial vaccine development. Conversely, an antigen preparation that was effective against needle challenge offered no protection against sand fly bite. These findings provide a new target for Leishmania vaccine development and demonstrate the critical role that the vector plays in the evaluation of candidate vaccines for leishmaniasis and other vectorborne diseases.

Item Type: Article
Journal or Publication Title: Journal of Infectious Diseases
Subjects: Q Science > QR Microbiology > QR355 Virology
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 56021
Deposited By: ep_importer_pure
Deposited On: 20 Jul 2012 12:01
Refereed?: Yes
Published?: Published
Last Modified: 09 Apr 2014 23:50
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/56021

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