Bates, Paul A (2007) Transmission of Leishmania metacyclic promastigotes by phlebotomine sand flies. International Journal of Parasitology, 37 (10). pp. 1097-1106. ISSN 0020-7519Full text not available from this repository.
A thorough understanding of the transmission mechanism of any infectious agent is crucial to implementing an effective intervention strategy. Here, our current understanding of the mechanisms that Leishmania parasites use to ensure their transmission from sand fly vectors by bite is reviewed. The most important mechanism is the creation of a "blocked fly" resulting from the secretion of promastigote secretory gel (PSG) by the parasites in the anterior midgut. This forces the sand fly to regurgitate PSG before it can bloodfeed, thereby depositing both PSG and infective metacyclic promastigotes in the skin of a mammalian host. Other possible factors in transmission are considered: damage to the stomodeal valve; occurrence of parasites in the salivary glands; and excretion of parasites from the anus of infected sand flies. Differences in the transmission mechanisms employed by parasites in the three subgenera, Leishmania, Viannia and Sauroleishmania are also addressed.
|Journal or Publication Title:||International Journal of Parasitology|
|Uncontrolled Keywords:||Leishmania ; Viannia ; Life cycle ; Promastigote secretory gel ; Metacyclic promastigotes ; Regurgitation ; Sand fly ; Saliva|
|Subjects:||Q Science > QR Microbiology > QR355 Virology|
|Departments:||Faculty of Health and Medicine > Biomedical & Life Sciences|
|Deposited On:||20 Jul 2012 12:01|
|Last Modified:||26 Jul 2012 20:45|
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