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New insights into the developmental biology and transmission mechanisms of Leishmania

Bates, P A and Rogers, M E (2004) New insights into the developmental biology and transmission mechanisms of Leishmania. Current molecular medicine, 4 (6). pp. 601-609. ISSN 1566-5240

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Abstract

Leishmania alternates between two main morphological forms in its life cycle: intracellular amastigotes in the mammalian host and motile promastigotes in the sandfly vector. Several different forms of promastigote can be recognised in sandfly infections. The first promastigote forms, which are found in the sandfly in the bloodmeal phase, are multiplicative procyclic promastigotes. These differentiate into nectomonad promastigotes, which are a non-dividing migratory stage moving from the posterior to the anterior midgut. When nectomonad promastigotes arrive at the anterior midgut they differentiate into leptomonad forms, a newly named life cycle stage, which resume replication. Leptomonad promastigotes, which are found in the anterior midgut, are the developmental precursors of the metacyclic promastigotes, the mammal-infective stages. Leptomonad forms also produce promastigote secretory gel, a substance that plays a key role in transmission by forming a physical obstruction in the gut, forcing the sandfly to regurgitate metacyclic promastigotes during bloodfeeding.

Item Type: Article
Journal or Publication Title: Current molecular medicine
Subjects: Q Science > QR Microbiology > QR180 Immunology
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 55983
Deposited By: ep_importer_pure
Deposited On: 19 Jul 2012 16:40
Refereed?: Yes
Published?: Published
Last Modified: 09 Apr 2014 23:50
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/55983

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