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Non-compartmental estimation of pharmacokinetic parameters for flexible sampling designs

Jaki, Thomas and Wolfsegger, Martin J. (2012) Non-compartmental estimation of pharmacokinetic parameters for flexible sampling designs. Statistics in Medicine, 31 (11-12). pp. 1059-1073.

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Abstract

Pharmacokinetic (PK) studies aim to understand the kinetics of absorption, distribution, metabolism and elimination of a drug. Typically, such studies involve measuring the concentration of the drug in the plasma or blood at several time points after drug administration. In studying the PK behaviour, either the non-compartmental approach or alternatively a modelling approach can be utilized. Traditionally, the non-compartmental approach makes minimal assumptions about the data-generating process but requires the data to be collected in a very structured way. Conversely, the modelling approach depends heavily on assumptions about the data-generating process but does not impose a specific data structure. In this paper, we will discuss non-compartmental methods for estimating the area under the concentration versus time curve and other common PK parameters that use minimal assumptions about the data structure making it applicable to a wide range of PK studies. We will evaluate the methods using simulation and give an illustrative example.

Item Type: Article
Journal or Publication Title: Statistics in Medicine
Uncontrolled Keywords: area under the concentration time curve ; AUC ; non-compartmental ; PK parameters ; sparse sampling
Subjects: Q Science > QA Mathematics
Departments: Faculty of Science and Technology > Mathematics and Statistics
ID Code: 54623
Deposited By: ep_importer_pure
Deposited On: 28 May 2012 11:41
Refereed?: Yes
Published?: Published
Last Modified: 09 Oct 2013 14:51
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/54623

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