Jaki, Thomas and Wolfsegger, Martin J. (2012) Non-compartmental estimation of pharmacokinetic parameters for flexible sampling designs. Statistics in Medicine, 31 (11-12). pp. 1059-1073.
Full text not available from this repository.Abstract
Pharmacokinetic (PK) studies aim to understand the kinetics of absorption, distribution, metabolism and elimination of a drug. Typically, such studies involve measuring the concentration of the drug in the plasma or blood at several time points after drug administration. In studying the PK behaviour, either the non-compartmental approach or alternatively a modelling approach can be utilized. Traditionally, the non-compartmental approach makes minimal assumptions about the data-generating process but requires the data to be collected in a very structured way. Conversely, the modelling approach depends heavily on assumptions about the data-generating process but does not impose a specific data structure. In this paper, we will discuss non-compartmental methods for estimating the area under the concentration versus time curve and other common PK parameters that use minimal assumptions about the data structure making it applicable to a wide range of PK studies. We will evaluate the methods using simulation and give an illustrative example.
| Item Type: | Article |
|---|---|
| Journal or Publication Title: | Statistics in Medicine |
| Uncontrolled Keywords: | area under the concentration time curve ; AUC ; non-compartmental ; PK parameters ; sparse sampling |
| Subjects: | Q Science > QA Mathematics |
| Departments: | Faculty of Science and Technology > Mathematics and Statistics |
| ID Code: | 54623 |
| Deposited By: | ep_importer_pure |
| Deposited On: | 28 May 2012 11:41 |
| Refereed?: | Yes |
| Published?: | Published |
| Last Modified: | 13 Dec 2012 13:33 |
| Identification Number: | |
| URI: | http://eprints.lancs.ac.uk/id/eprint/54623 |
Actions (login required)
| View Item |
