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A generalized Dunnett Test for Multi-arm Multi-stage Clinical Studies with Treatment Selection

Magirr, Dominic and Jaki, Thomas and Whitehead, John (2012) A generalized Dunnett Test for Multi-arm Multi-stage Clinical Studies with Treatment Selection. Biometrika, 99 (2). pp. 494-501. ISSN 0006-3444

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Abstract

We generalize the Dunnett test to derive efficacy and futility boundaries for a flexible multi-arm multi-stage clinical trial for a normally distributed endpoint with known variance. We show that the boundaries control the familywise error rate in the strong sense. The method is applicable for any number of treatment arms, number of stages and number of patients per treatment per stage. It can be used for a wide variety of boundary types or rules derived from α-spending functions. Additionally, we show how sample size can be computed under a least favourable configuration power requirement and derive formulae for expected sample sizes.

Item Type: Article
Journal or Publication Title: Biometrika
Uncontrolled Keywords: Clinical trial ; Dunnett test ; Familywise error rate ; Treatment selection
Subjects: Q Science > QA Mathematics
Departments: Faculty of Science and Technology > Mathematics and Statistics
ID Code: 54620
Deposited By: ep_importer_pure
Deposited On: 28 May 2012 11:48
Refereed?: Yes
Published?: Published
Last Modified: 09 Oct 2013 14:49
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/54620

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