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DNA end-processing enzyme polynucleotide kinase as a potential target in the treatment of cancer

Allinson, Sarah (2010) DNA end-processing enzyme polynucleotide kinase as a potential target in the treatment of cancer. Future Oncology, 6 (6). pp. 1031-1042. ISSN 1479-6694

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Abstract

Pharmacological inhibition of DNA-repair pathways as an approach for the potentiation of chemo- and radio-therapeutic cancer treatments has attracted increasing levels of interest in recent years. Inhibitors of several enzymes involved in the repair of DNA strand breaks are currently at various stages of the drug development process. Polynucleotide kinase (PNK), a bifunctional DNA-repair enzyme that possesses both 3'-phosphatase and 5'-kinase activities, plays an important role in the repair of both single strand and double strand breaks and as a result, RNAi-mediated knockdown of PNK sensitizes cells to a range of DNA-damaging agents. Recently, a small molecule inhibitor of PNK has been developed that is able to sensitize cells to ionizing radiation and the topoisomerase I poison, camptothecin. Although still in the early stages of development, PNK inhibition represents a promising means of enhancing the efficacy of existing cancer treatments.

Item Type: Article
Journal or Publication Title: Future Oncology
Subjects:
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 53919
Deposited By: ep_importer_pure
Deposited On: 03 May 2012 14:23
Refereed?: Yes
Published?: Published
Last Modified: 21 Sep 2017 04:52
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/53919

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