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Nutritional Immunology: A Multi-Dimensional Approach

Ponton, Fleur and Wilson, Kenneth and Cotter, Sheena C. and Raubenheimer, David and Simpson, Stephen J. (2011) Nutritional Immunology: A Multi-Dimensional Approach. PLoS pathogens, 7 (12). -. ISSN 1553-7374

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Abstract

Nutrition is critical to immune defence and resistance to pathogens, with consequences that affect the health, welfare, and reproductive success of individual organisms [1], [2], and also has profound ecological and evolutionary implications [3]–[5]. In humans, under-nutrition, notably of protein, is a major contributor to morbidity and mortality due to infectious diseases, particularly in the developing world [1]. Likewise, over-nutrition and its associated metabolic disorders may impair immune function, disrupt the relationship with symbiotic and commensal microbiota, and increase susceptibility to infectious disease [6]. Despite the undoubted importance of nutrition to immune defence, the challenge remains to capture the complexity of this relationship. There are three main aspects to this complexity: (i) nutrition is a complex multi-dimensional problem for hosts, pathogens, and commensals; (ii) host immunity is a complex, multi-dimensional trait; and (iii) nutrition and immunity interact via multiple direct and indirect pathways, including involvement of the host's microbiota.

Item Type: Article
Journal or Publication Title: PLoS pathogens
Uncontrolled Keywords: LARVAL HELIOTHIS-VIRESCENS ; ECOLOGICAL IMMUNOLOGY ; IMMUNE-SYSTEM ; SELENIUM SUPPLEMENTATION ; EVOLUTIONARY ECOLOGY ; FEEDING-BEHAVIOR ; INNATE IMMUNITY ; GUT MICROBIOME ; PROTEIN COSTS ; TRADE-OFFS
Subjects:
Departments: Faculty of Science and Technology > Lancaster Environment Centre
ID Code: 53496
Deposited By: ep_importer_pure
Deposited On: 13 Apr 2012 12:14
Refereed?: Yes
Published?: Published
Last Modified: 09 Apr 2014 23:17
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/53496

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