Ponton, Fleur and Wilson, Kenneth and Cotter, Sheena C. and Raubenheimer, David and Simpson, Stephen J. (2011) Nutritional Immunology: A Multi-Dimensional Approach. PLoS pathogens, 7 (12). -. ISSN 1553-7374Full text not available from this repository.
Nutrition is critical to immune defence and resistance to pathogens, with consequences that affect the health, welfare, and reproductive success of individual organisms , , and also has profound ecological and evolutionary implications –. In humans, under-nutrition, notably of protein, is a major contributor to morbidity and mortality due to infectious diseases, particularly in the developing world . Likewise, over-nutrition and its associated metabolic disorders may impair immune function, disrupt the relationship with symbiotic and commensal microbiota, and increase susceptibility to infectious disease . Despite the undoubted importance of nutrition to immune defence, the challenge remains to capture the complexity of this relationship. There are three main aspects to this complexity: (i) nutrition is a complex multi-dimensional problem for hosts, pathogens, and commensals; (ii) host immunity is a complex, multi-dimensional trait; and (iii) nutrition and immunity interact via multiple direct and indirect pathways, including involvement of the host's microbiota.
|Journal or Publication Title:||PLoS pathogens|
|Uncontrolled Keywords:||LARVAL HELIOTHIS-VIRESCENS ; ECOLOGICAL IMMUNOLOGY ; IMMUNE-SYSTEM ; SELENIUM SUPPLEMENTATION ; EVOLUTIONARY ECOLOGY ; FEEDING-BEHAVIOR ; INNATE IMMUNITY ; GUT MICROBIOME ; PROTEIN COSTS ; TRADE-OFFS|
|Departments:||Faculty of Science and Technology > Lancaster Environment Centre|
|Deposited On:||13 Apr 2012 12:14|
|Last Modified:||26 Jul 2012 20:15|
Actions (login required)