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Gerstmann-Sträussler-Scheinker disease showing β-protein type cerebellar and cerebral amyloid angiopathy

Ikeda, S I and Yanagisawa, N and Allsop, D and Glenner, G G (1994) Gerstmann-Sträussler-Scheinker disease showing β-protein type cerebellar and cerebral amyloid angiopathy. Acta Neuropathologica, 88 (3). pp. 262-266. ISSN 0001-6322

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Cerebral amyloid angiopathy is observed in several brain degenerative disorders, but this pathological condition has received little attention in Gerstmann-Sträussler-Scheinker disease (GSS). We report a 69-year-old man who showed the cardinal features of GSS together with typical and extensive congophilic angiopathy. Immunohistochemical studies revealed that the vast majority of the amyloid plaques present in the brain of this patient were consistently labeled by anti-prion protein (PrP) antibody. Double immunostaining disclosed many additional beta-protein immunoreactive plaque-like lesions, including a special type of "hybrid" plaque with colocalization of PrP and beta-protein (beta-PrP). The vascular amyloid deposits seen in both the cerebellum and cerebrum were immunoreactive only to anti-beta-protein antibody. It seems likely that the extensive deposition of beta-protein amyloid (including brain vascular amyloidosis) seen in this and other similar cases is part of pathology of GSS, although the possibility that this finding is due to ageing or concomitant Alzheimer's disease cannot be completely ruled out.

Item Type: Journal Article
Journal or Publication Title: Acta Neuropathologica
Uncontrolled Keywords: Aged ; Amyloid beta-Peptides ; Amyloidosis ; Brain ; Cerebellum ; Cerebrovascular Disorders ; Gerstmann-Straussler-Scheinker Disease ; Humans ; Immunohistochemistry ; Male ; Prions
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 53098
Deposited By: ep_importer_pure
Deposited On: 09 Mar 2012 02:51
Refereed?: Yes
Published?: Published
Last Modified: 11 Apr 2018 00:17
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