Pickup, D. M. and Moss, R. M. and Qiu, D. and Newport, R. J. and Valappil, S. P. and Knowles, J. C. and Smith, Mark E. (2009) Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses. Journal of Chemical Physics, 130 (6).Full text not available from this repository.
Antimicrobial gallium-doped phosphate-based glasses of general composition (P2O5)(0.45)(CaO)(0.16)(Na2O)(0.39-x)(Ga2O3)(x) (where x=0, 0.01, 0.03, and 0.05) have been studied using the advanced synchrotron-based techniques of Ga K-edge x-ray absorption spectroscopy and high-energy x-ray diffraction to provide a structural insight into their unique properties. The results show that the Ga3+ ions are octahedrally coordinated. Furthermore, substitution of Na2O by Ga2O3 strengthens the phosphate network structure because the presence of GaO6 octahedra inhibits the migration of the remaining Na+ ions. The results are discussed in terms of the use of Na2O-CaO-P2O5 glasses as controlled-delivery devices for antimicrobial Ga3+ ions in biomedical applications. We are thereby able to relate the atomic-scale environment of the Ga3+ ions beneficially to the glass dissolution, and thus to their ability to disrupt bacterial cell activity by usurping the role of iron.
|Journal or Publication Title:||Journal of Chemical Physics|
|Uncontrolled Keywords:||antibacterial activity, biomedical materials, calcium compounds, cellular biophysics, dissolving, gallium, microorganisms, phosphate glasses, sodium compounds, X-ray absorption spectra, X-ray diffraction|
|Deposited On:||28 Feb 2012 13:17|
|Last Modified:||07 Jan 2015 17:15|
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