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Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses

Pickup, D. M. and Moss, R. M. and Qiu, D. and Newport, R. J. and Valappil, S. P. and Knowles, J. C. and Smith, Mark E. (2009) Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses. Journal of Chemical Physics, 130 (6).

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Abstract

Antimicrobial gallium-doped phosphate-based glasses of general composition (P2O5)(0.45)(CaO)(0.16)(Na2O)(0.39-x)(Ga2O3)(x) (where x=0, 0.01, 0.03, and 0.05) have been studied using the advanced synchrotron-based techniques of Ga K-edge x-ray absorption spectroscopy and high-energy x-ray diffraction to provide a structural insight into their unique properties. The results show that the Ga3+ ions are octahedrally coordinated. Furthermore, substitution of Na2O by Ga2O3 strengthens the phosphate network structure because the presence of GaO6 octahedra inhibits the migration of the remaining Na+ ions. The results are discussed in terms of the use of Na2O-CaO-P2O5 glasses as controlled-delivery devices for antimicrobial Ga3+ ions in biomedical applications. We are thereby able to relate the atomic-scale environment of the Ga3+ ions beneficially to the glass dissolution, and thus to their ability to disrupt bacterial cell activity by usurping the role of iron.

Item Type: Article
Journal or Publication Title: Journal of Chemical Physics
Uncontrolled Keywords: antibacterial activity, biomedical materials, calcium compounds, cellular biophysics, dissolving, gallium, microorganisms, phosphate glasses, sodium compounds, X-ray absorption spectra, X-ray diffraction
Subjects:
Departments: VC's Office
ID Code: 52831
Deposited By: ep_importer_pure
Deposited On: 28 Feb 2012 13:17
Refereed?: Yes
Published?: Published
Last Modified: 09 Apr 2014 23:09
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/52831

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