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Preparation, structural characterisation and antibacterial properties of Ga-doped sol-gel phosphate-based glass

Pickup, D. M. and Valappil, S. P. and Moss, R. M. and Twyman, H. L. and Guerry, Paul and Smith, Mark E. and Wilson, M. and Knowles, J. C. and Newport, R. J. (2009) Preparation, structural characterisation and antibacterial properties of Ga-doped sol-gel phosphate-based glass. Journal of Materials Science: Materials in Medicine, 44 (7). pp. 1858-1867.

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Abstract

A sol-gel preparation of Ga-doped phosphate-based glass with potential application in antimicrobial devices has been developed. Samples of composition (CaO)(0.30)(Na2O)(0.20-x) (Ga2O3) (x) (P2O5)(0.50) where x = 0 and 0.03 were prepared, and the structure and properties of the gallium-doped sample compared with those of the sample containing no gallium. Analysis of the P-31 MAS NMR data demonstrated that addition of gallium to the sol-gel reaction increases the connectivity of the phosphate network at the expense of hydroxyl groups. This premise is supported by the results of the elemental analysis, which showed that the gallium-free sample contains significantly more hydrogen and by FTIR spectroscopy, which revealed a higher concentration of -OH groups in that sample. Ga K-edge extended X-ray absorption fine structure and X-ray absorption near-edge structure data revealed that the gallium ions are coordinated by six oxygen atoms. In agreement with the X-ray absorption data, the high-energy XRD results also suggest that the Ga3? ions are octahedrally coordinated with respect to oxygen. Antimicrobial studies demonstrated that the sample containing Ga3+ ions had significant activity against Staphylococcus aureus compared to the control.

Item Type: Article
Journal or Publication Title: Journal of Materials Science: Materials in Medicine
Uncontrolled Keywords: X-RAY-ABSORPTION ; P-31 MAS-NMR ; FINE-STRUCTURE ; STREPTOCOCCUS-SANGUIS ; IRON-METABOLISM ; GALLIUM ; DIFFRACTION ; TRANSITION ; BIOFILMS ; CRYSTAL
Subjects: UNSPECIFIED
Departments: VC's Office
Faculty of Science and Technology > Physics
ID Code: 52829
Deposited By: ep_importer_pure
Deposited On: 28 Feb 2012 13:11
Refereed?: Yes
Published?: Published
Last Modified: 09 Apr 2014 23:09
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/52829

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