Munkley, Jennifer and Copeland, Nikki A and Moignard, Victoria and Knight, John R P and Greaves, Erin and Ramsbottom, Simon A and Pownall, Mary E and Southgate, Jennifer and Ainscough, Justin F-X and Coverley, Dawn (2011) Cyclin E is recruited to the nuclear matrix during differentiation, but is not recruited in cancer cells. Nucleic Acids Research, 39 (7). pp. 2671-2677.
Full text not available from this repository.Abstract
Cyclin E supports pre-replication complex (pre-RC) assembly, while cyclin A-associated kinase activates DNA synthesis. We show that cyclin E, but not A, is mounted upon the nuclear matrix in sub-nuclear foci in differentiated vertebrate cells, but not in undifferentiated cells or cancer cells. In murine embryonic stem cells, Xenopus embryos and human urothelial cells, cyclin E is recruited to the nuclear matrix as cells differentiate and this can be manipulated in vitro. This suggests that pre-RC assembly becomes spatially restricted as template usage is defined. Furthermore, failure to become restricted may contribute to the plasticity of cancer cells.
| Item Type: | Article |
|---|---|
| Journal or Publication Title: | Nucleic Acids Research |
| Uncontrolled Keywords: | Active Transport, Cell Nucleus ; Animals ; Cell Differentiation ; Cell Line, Tumor ; Cells, Cultured ; Cyclin E ; Humans ; Mice ; Neoplasms ; Nuclear Matrix ; Protein Transport ; Xenopus laevis |
| Subjects: | UNSPECIFIED |
| Departments: | Faculty of Health and Medicine > Biomedical & Life Sciences |
| ID Code: | 52421 |
| Deposited By: | ep_importer_pure |
| Deposited On: | 27 Jan 2012 12:31 |
| Refereed?: | Yes |
| Published?: | Published |
| Last Modified: | 26 Jul 2012 20:05 |
| Identification Number: | |
| URI: | http://eprints.lancs.ac.uk/id/eprint/52421 |
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