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An observational prospective study of topical acidified nitrite for killing methicillin-resistant Staphylococcus aureus (MRSA) in contaminated wounds

Ormerod, Anthony D. and Shah, Amjad A. J. and Li, Hong and Benjamin, Nigel and Ferguson, Gail P. and Leifert, Carlo (2011) An observational prospective study of topical acidified nitrite for killing methicillin-resistant Staphylococcus aureus (MRSA) in contaminated wounds. BMC Research Notes, 4. ISSN 1756-0500

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    Abstract

    Background Endogenous nitric oxide (NO) kills bacteria and other organisms as part of the innate immune response. When nitrite is exposed to low pH, NO is generated and has been used as an NO delivery system to treat skin infections. We demonstrated eradication of MRSA carriage from wounds using a topical formulation of citric acid (4.5%) and sodium nitrite (3%) creams co-applied for 5 days to 15 wounds in an observational prospective pilot study of 8 patients. Findings Following treatment with topical citric acid and sodium nitrite, 9 of 15 wounds (60%) and 3 of 8 patients (37%) were cleared of infection. MRSA isolates from these patients were all sensitive to acidified nitrite in vitro compared to methicillin-sensitive S. aureus and a reference strain of MRSA. Conclusions Nitric oxide and acidified nitrite offer a novel therapy for control of MRSA in wounds. Wounds that were not cleared of infection may have been re-contaminated or the bioavailability of acidified nitrite impaired by local factors in the tissue.

    Item Type: Article
    Journal or Publication Title: BMC Research Notes
    Subjects: UNSPECIFIED
    Departments: Faculty of Science and Technology > Lancaster Environment Centre
    ID Code: 52393
    Deposited By: ep_importer_pure
    Deposited On: 24 Jan 2012 10:32
    Refereed?: Yes
    Published?: Published
    Last Modified: 09 Apr 2014 23:02
    Identification Number:
    URI: http://eprints.lancs.ac.uk/id/eprint/52393

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