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Investigating the assumption of homogeneity of treatment effects in clincal studies with application to meta-analysis

Julious, Steven and Whitehead, Anne (2012) Investigating the assumption of homogeneity of treatment effects in clincal studies with application to meta-analysis. Pharmaceutical Statistics, 11 (1). pp. 49-56. ISSN 1539-1604

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Abstract

An important part of the evaluation of a therapy is an investigation of the assumption of homogeneity of its effect across pre-defined subpopulations. In this paper we describe simple graphical presentations that could be used to assess the homogeneity of treatment effect and identify outliers. The emphasis in the paper is on meta-analysis but the methods described can be generalized to other investigations.

Item Type: Article
Journal or Publication Title: Pharmaceutical Statistics
Uncontrolled Keywords: meta-analysis ; clinical trials ; normal probability plots ; simulated envelopes ; bootstrapping
Subjects: Q Science > QA Mathematics
Departments: Faculty of Science and Technology > Mathematics and Statistics
ID Code: 52183
Deposited By: ep_importer_pure
Deposited On: 21 Dec 2011 09:54
Refereed?: Yes
Published?: Published
Last Modified: 09 Apr 2014 22:59
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/52183

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