Liotta, Lisa and Medina, Irene and Robinson, Jennifer and Carroll, Chris and Pan, Po-Shen and Corral, Ricardo and Johnston, Jennifer and Cook, Kristina and Curtis, Fiona and Sharples, Gary and McAlpine, Shelli (2004) Novel antibiotics: second generation macrocyclic peptides designed to trap Holliday junctions. Tetrahedron Letters, 45 (46). pp. 8447-8450. ISSN 0040-4039
Full text not available from this repository.Abstract
Described are the syntheses of 15 macrocyclic peptides designed to trap Holliday junctions (HJs) in bacteria during site-specific and homologous recombination. This leads to inhibiting bacterial growth. These second generation macrocycles were based on the C-2 symmetrical HJ. They were synthesized using a strategy that permits elucidation of the amino acid role in binding HJs. The syntheses of these macrocycles are an important step in the development of a new class of antibiotics.
| Item Type: | Article |
|---|---|
| Journal or Publication Title: | Tetrahedron Letters |
| Subjects: | UNSPECIFIED |
| Departments: | Faculty of Health and Medicine > Medicine |
| ID Code: | 51951 |
| Deposited By: | ep_importer_pure |
| Deposited On: | 09 Dec 2011 11:46 |
| Refereed?: | Yes |
| Published?: | Published |
| Last Modified: | 26 Jul 2012 19:58 |
| Identification Number: | |
| URI: | http://eprints.lancs.ac.uk/id/eprint/51951 |
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