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Novel antibiotics: second generation macrocyclic peptides designed to trap Holliday junctions

Liotta, Lisa and Medina, Irene and Robinson, Jennifer and Carroll, Chris and Pan, Po-Shen and Corral, Ricardo and Johnston, Jennifer and Cook, Kristina and Curtis, Fiona and Sharples, Gary and McAlpine, Shelli (2004) Novel antibiotics: second generation macrocyclic peptides designed to trap Holliday junctions. Tetrahedron Letters, 45 (46). pp. 8447-8450. ISSN 0040-4039

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Abstract

Described are the syntheses of 15 macrocyclic peptides designed to trap Holliday junctions (HJs) in bacteria during site-specific and homologous recombination. This leads to inhibiting bacterial growth. These second generation macrocycles were based on the C-2 symmetrical HJ. They were synthesized using a strategy that permits elucidation of the amino acid role in binding HJs. The syntheses of these macrocycles are an important step in the development of a new class of antibiotics.

Item Type: Article
Journal or Publication Title: Tetrahedron Letters
Subjects: UNSPECIFIED
Departments: Faculty of Health and Medicine > Medicine
ID Code: 51951
Deposited By: ep_importer_pure
Deposited On: 09 Dec 2011 11:46
Refereed?: Yes
Published?: Published
Last Modified: 09 Apr 2014 22:56
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/51951

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