Liotta, Lisa and Medina, Irene and Robinson, Jennifer and Carroll, Chris and Pan, Po-Shen and Corral, Ricardo and Johnston, Jennifer and Cook, Kristina and Curtis, Fiona and Sharples, Gary and McAlpine, Shelli (2004) Novel antibiotics: second generation macrocyclic peptides designed to trap Holliday junctions. Tetrahedron Letters, 45 (46). pp. 8447-8450. ISSN 0040-4039Full text not available from this repository.
Described are the syntheses of 15 macrocyclic peptides designed to trap Holliday junctions (HJs) in bacteria during site-specific and homologous recombination. This leads to inhibiting bacterial growth. These second generation macrocycles were based on the C-2 symmetrical HJ. They were synthesized using a strategy that permits elucidation of the amino acid role in binding HJs. The syntheses of these macrocycles are an important step in the development of a new class of antibiotics.
|Journal or Publication Title:||Tetrahedron Letters|
|Departments:||Faculty of Health and Medicine > Medicine|
|Deposited On:||09 Dec 2011 11:46|
|Last Modified:||26 Jul 2012 19:58|
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