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Modulation of β-amyloid production and fibrillisation

Allsop, David and Twyman, Lance and Davies, Yvonne and Moore, Susan and York, Amber and Swanson, Linda and Soutar, Ian (2000) Modulation of β-amyloid production and fibrillisation. Biochemical Society Symposia, 67. pp. 1-14. ISSN 1744-1439

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Abstract

Alzheimer’s disease (AD) is the most common cause of dementia in old age and presently affects an estimated 4 million people in the U.S.A. and 0.75 million people in the U.K. It is a relentless, degenerative brain disease, characterized by progressive cognitive impairment. In the final stages of the disease, patients are often bedridden, doubly incontinent and unable to speak or to recognize close relatives. Pathological changes of Alzheimer’s disease include extensive neuronal loss and the presence of numerous neurofibrillary tangles and senile plaques in the brain. The senile plaques contain amyloid fibrils derived from a 39-43-amino-acid peptide referred to as b-amyloid or Ab. The basic theory of the so-called ‘amyloid hypothesis’ is that the deposition of aggregated forms of Ab in the brain parenchyma triggers a pathological cascade of events that leads to neurofibrillary tangle formation, neuronal loss and the associated dementia [1]. Here we discuss progress towards the identification of inhibitors of Ab production and fibrillization.

Item Type: Article
Journal or Publication Title: Biochemical Society Symposia
Subjects:
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 51360
Deposited By: ep_importer_pure
Deposited On: 22 Nov 2011 16:25
Refereed?: Yes
Published?: Published
Last Modified: 09 Apr 2014 22:51
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/51360

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