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Culture of dermal fibroblasts and protein adsorption on block conetworks of poly(butyl methacrylate-block-(2,3 propandiol-1-methacrylate-stat-ethandiol dimethacrylate))

Sun, Yun and Collett, Jon and Fullwood, Nigel J. and Mac Neil, Sheila and Rimmer, S. (2007) Culture of dermal fibroblasts and protein adsorption on block conetworks of poly(butyl methacrylate-block-(2,3 propandiol-1-methacrylate-stat-ethandiol dimethacrylate)). Biomaterials, 28 (4). pp. 661-670. ISSN 0142-9612

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Abstract

Amphiphilic block terpolymer conetworks composed of butyl methacrylate (BMA), 2,3 propandiol-l-methacrylate (GMMA) and ethandiol dimethacrylate (EDMA) were synthesized. Telechelic oligomers with the carboxylic acid end groups were made via ozonolysis of poly(BMA-co-butadiene) and then these were reacted with glycidyl methacrylate to obtain cross-linkable vinyl groups at both chain ends. Networks were then formed via free radical copolymerization with EDMA and GMMA or 2-methyl-acrylic acid 2,2-dimethyl[1,3]dioxolan-4-ylmethyl ester (GMAc). The acetonide groups of the GMAc units were then removed, by reaction with selenium dioxide and hydrogen peroxide, to give networks with the same molecular structure as the GMMA terpolymers but different cell adhesion and protein adsorption properties. Protein adsorption was maximised in networks prepared with GMMA rather than with GMAc followed by removal of the acetonide. Block conetworks that were synthesised with GMAc were poor substrates for cell proliferation whilst the GMMA class support good levels of both cell viability and proliferation. It is suggested that the difference in behaviour is derived from changes in the surface composition. (c) 2006 Elsevier Ltd. All rights reserved.

Item Type: Article
Journal or Publication Title: Biomaterials
Uncontrolled Keywords: amphiphilic conetwork ; protein adsorption ; cell culture ; fibroblast ; BABOON FIBRINOGEN ADSORPTION ; AMPHIPHILIC NETWORKS ; EXTRACELLULAR-MATRIX ; ADHESION ; FIBRONECTIN ; SCAFFOLDS ; HYDROGEL ; PROLIFERATION ; ARCHITECTURE ; MEMBRANES
Subjects:
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 51135
Deposited By: ep_importer_pure
Deposited On: 18 Nov 2011 09:46
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 19:47
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/51135

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