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Modelled and measured arsenic exposure around a power station in Slovakia

Keegan, T. J. and Nieuwenhuijsen, M. J. and Pesch, B. and Ranft, U. and Thornton, I. and , EXPASCAN Study Grp (2012) Modelled and measured arsenic exposure around a power station in Slovakia. Applied Geochemistry, 27 (5). pp. 1013-1019.

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Abstract

In 1999-2000 an epidemiological study was carried out to investigate arsenic exposure and risk of nonmelanoma skin cancer in the population around a power station in Slovakia. As part of the exposure assessment for that study, markers of physiological exposure to arsenic (urinary arsenic and nail arsenic) and measures of environmental arsenic were taken. Residential history and arsenic emissions were combined in a measure used to classify the study population's exposure. Here, we take a model designed to estimate the daily arsenic absorption and urinary arsenic excretion developed by the US EPA and compare its output to the values for measured urinary arsenic, measured environmental arsenic and modelled food arsenic used in the previous study. We found that the US EPA model underestimated arsenic exposure in this population. Potential misclassification compared to the exposure used previously was also quantified, with poor agreement between a measured biomarker of current arsenic exposure and modelled estimates of arsenic uptake and excretion. (C) 2011 Published by Elsevier Ltd.

Item Type: Article
Journal or Publication Title: Applied Geochemistry
Subjects: R Medicine > R Medicine (General)
Departments: Faculty of Health and Medicine > Medicine
ID Code: 51118
Deposited By: ep_importer_pure
Deposited On: 17 Nov 2011 10:16
Refereed?: Yes
Published?: Published
Last Modified: 15 Oct 2013 10:18
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/51118

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