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Monoclonal antibodies raised against a subsequence of senile plaque core protein react with plaque cores, plaque periphery and cerebrovascular amyloid in Alzheimer's disease

Allsop, D and Landon, M and Kidd, M and Lowe, J S and Reynolds, G P and Gardner, A (1986) Monoclonal antibodies raised against a subsequence of senile plaque core protein react with plaque cores, plaque periphery and cerebrovascular amyloid in Alzheimer's disease. Neuroscience Letters, 68 (2). pp. 252-6. ISSN 0304-3940

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Abstract

Four monoclonal antibodies (1D2/1/2, 1G10/2/3, 3B6/1/1, 4D12/2/6) were raised against a synthetic peptide consisting of residues 8-17 of a protein reported to be common to senile plaque cores, cerebrovascular amyloid and neurofibrillary tangles in Alzheimer's disease. In an immunoperoxidase study of Alzheimer brain tissue, these antibodies stained plaque and vascular amyloid but not tangles, suggesting that the polypeptide chain in the region of residues 8-17 is exposed in the former two but, if present, inaccessible in the latter. In addition, staining of granular material in the plaque periphery was observed. These antibodies will be useful tools for future work on the origin of this protein.

Item Type: Article
Journal or Publication Title: Neuroscience Letters
Uncontrolled Keywords: Alzheimer Disease ; Amyloid ; Antibodies, Monoclonal ; Blood Vessels ; Cerebral Cortex ; Humans ; Nerve Tissue Proteins ; Neurofibrils
Subjects:
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 50873
Deposited By: ep_importer_pure
Deposited On: 01 Nov 2011 16:16
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 19:44
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/50873

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