Allsop, D and Landon, M and Kidd, M and Lowe, J S and Reynolds, G P and Gardner, A (1986) Monoclonal antibodies raised against a subsequence of senile plaque core protein react with plaque cores, plaque periphery and cerebrovascular amyloid in Alzheimer's disease. Neuroscience Letters, 68 (2). pp. 252-6. ISSN 0304-3940Full text not available from this repository.
Four monoclonal antibodies (1D2/1/2, 1G10/2/3, 3B6/1/1, 4D12/2/6) were raised against a synthetic peptide consisting of residues 8-17 of a protein reported to be common to senile plaque cores, cerebrovascular amyloid and neurofibrillary tangles in Alzheimer's disease. In an immunoperoxidase study of Alzheimer brain tissue, these antibodies stained plaque and vascular amyloid but not tangles, suggesting that the polypeptide chain in the region of residues 8-17 is exposed in the former two but, if present, inaccessible in the latter. In addition, staining of granular material in the plaque periphery was observed. These antibodies will be useful tools for future work on the origin of this protein.
|Journal or Publication Title:||Neuroscience Letters|
|Uncontrolled Keywords:||Alzheimer Disease ; Amyloid ; Antibodies, Monoclonal ; Blood Vessels ; Cerebral Cortex ; Humans ; Nerve Tissue Proteins ; Neurofibrils|
|Departments:||Faculty of Health and Medicine > Biomedical & Life Sciences|
|Deposited On:||01 Nov 2011 16:16|
|Last Modified:||04 Mar 2016 03:15|
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