Allsop, D and Kidd, M and Landon, M and Tomlinson, A (1986) Isolated senile plaque cores in Alzheimer's disease and Down's syndrome show differences in morphology. Journal of Neurology, Neurosurgery and Psychiatry, 49 (8). pp. 886-892. ISSN 0022-3050Full text not available from this repository.
Frontal and temporal cortical tissue from the brains of elderly cases of Down's syndrome was used to make preparations of neuronal cell bodies containing senile plaque cores. Polarisation microscopy revealed normal "classical" plaque cores, and also a high proportion of unusual "amorphous" plaque cores which we have not seen in Alzheimer's disease. These two forms were easily distinguished by electron microscopy. This suggests that late Down's syndrome may not be an exact model for Alzheimer's disease.
|Journal or Publication Title:||Journal of Neurology, Neurosurgery and Psychiatry|
|Uncontrolled Keywords:||Alzheimer Disease ; Down Syndrome ; Frontal Lobe ; Humans ; Microscopy, Electron ; Temporal Lobe|
|Departments:||Faculty of Health and Medicine > Biomedical & Life Sciences|
|Deposited On:||01 Nov 2011 16:16|
|Last Modified:||07 Jan 2015 17:00|
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