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Isolated senile plaque cores in Alzheimer's disease and Down's syndrome show differences in morphology

Allsop, D and Kidd, M and Landon, M and Tomlinson, A (1986) Isolated senile plaque cores in Alzheimer's disease and Down's syndrome show differences in morphology. Journal of Neurology Neurosurgery and Psychiatry, 49 (8). pp. 886-92.

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Abstract

Frontal and temporal cortical tissue from the brains of elderly cases of Down's syndrome was used to make preparations of neuronal cell bodies containing senile plaque cores. Polarisation microscopy revealed normal "classical" plaque cores, and also a high proportion of unusual "amorphous" plaque cores which we have not seen in Alzheimer's disease. These two forms were easily distinguished by electron microscopy. This suggests that late Down's syndrome may not be an exact model for Alzheimer's disease.

Item Type: Article
Journal or Publication Title: Journal of Neurology Neurosurgery and Psychiatry
Uncontrolled Keywords: Alzheimer Disease ; Down Syndrome ; Frontal Lobe ; Humans ; Microscopy, Electron ; Temporal Lobe
Subjects: UNSPECIFIED
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 50872
Deposited By: ep_importer_pure
Deposited On: 01 Nov 2011 16:16
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 19:44
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/50872

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