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Immunogold labeling of cerebrovascular and neuritic plaque amyloid fibrils in Alzheimer's disease with an anti-β protein monoclonal antibody

Ikeda, S and Wong, C W and Allsop, D and Landon, M and Kidd, M and Glenner, G G (1987) Immunogold labeling of cerebrovascular and neuritic plaque amyloid fibrils in Alzheimer's disease with an anti-β protein monoclonal antibody. Laboratory investigation; a journal of technical methods and pathology, 57 (4). pp. 446-9. ISSN 0023-6837

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Abstract

A monoclonal antibody raised to a synthetic peptide consisting of residues 8 to 17 of the amyloid beta protein of Alzheimer's disease was employed for immunogold electron microscopic studies on amyloid fibrils of cerebrovascular walls and neuritic plaques in this disease. Electron microscopy revealed a specific gold labeling of the amyloid fibrils in these structures. This provides ultrastructural evidence that beta protein is intimately associated with the amyloid fibril. With previous chemical evidence, this observation supports the concentration that it is an intrinsic component of the fibril.

Item Type: Article
Journal or Publication Title: Laboratory investigation; a journal of technical methods and pathology
Uncontrolled Keywords: Alzheimer Disease ; Amyloid ; Amyloid beta-Peptides ; Antibodies, Monoclonal ; Humans ; Immunoenzyme Techniques ; Immunohistochemistry ; Microscopy, Electron ; Neurofibrils
Subjects: UNSPECIFIED
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 50871
Deposited By: ep_importer_pure
Deposited On: 01 Nov 2011 16:15
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 19:44
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/50871

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