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Cerebrovascular amyloid in scrapie-affected sheep reacts with antibodies to prion protein

Allsop, D and Ikeda, S and Bruce, M and Glenner, G G (1988) Cerebrovascular amyloid in scrapie-affected sheep reacts with antibodies to prion protein. Neuroscience Letters, 92 (2). pp. 234-239. ISSN 0304-3940

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Abstract

In an immunohistochemical study of naturally-occurring and experimental scrapie in sheep, deposits of cerebrovascular amyloid were found to react with antibodies to hamster scrapie prion protein (PrP 27-30), but not with antibodies to the amyloid beta-protein of Alzheimer's disease. It is concluded that this vascular amyloid is formed from PrP and is therefore closely associated with scrapie infection. It is likely that this amyloid is formed from a host precursor protein as a specific pathological consequence of invasion by the scrapie agent.

Item Type: Article
Journal or Publication Title: Neuroscience Letters
Uncontrolled Keywords: Amyloid ; Animals ; Brain ; Cerebrovascular Circulation ; Cricetinae ; Immunohistochemistry ; Prions ; Scrapie ; Sheep
Subjects: UNSPECIFIED
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 50868
Deposited By: ep_importer_pure
Deposited On: 08 Nov 2011 11:44
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 19:44
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/50868

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