Allsop, D and Ikeda, S and Bruce, M and Glenner, G G (1988) Cerebrovascular amyloid in scrapie-affected sheep reacts with antibodies to prion protein. Neuroscience Letters, 92 (2). pp. 234-239. ISSN 0304-3940Full text not available from this repository.
In an immunohistochemical study of naturally-occurring and experimental scrapie in sheep, deposits of cerebrovascular amyloid were found to react with antibodies to hamster scrapie prion protein (PrP 27-30), but not with antibodies to the amyloid beta-protein of Alzheimer's disease. It is concluded that this vascular amyloid is formed from PrP and is therefore closely associated with scrapie infection. It is likely that this amyloid is formed from a host precursor protein as a specific pathological consequence of invasion by the scrapie agent.
|Journal or Publication Title:||Neuroscience Letters|
|Uncontrolled Keywords:||Amyloid ; Animals ; Brain ; Cerebrovascular Circulation ; Cricetinae ; Immunohistochemistry ; Prions ; Scrapie ; Sheep|
|Departments:||Faculty of Health and Medicine > Biomedical & Life Sciences|
|Deposited On:||08 Nov 2011 11:44|
|Last Modified:||07 Jan 2015 17:00|
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