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Evidence of amyloid β-protein immunoreactive early plaque lesions in Down's syndrome brains

Ikeda, S and Yanagisawa, N and Allsop, D and Glenner, G G (1989) Evidence of amyloid β-protein immunoreactive early plaque lesions in Down's syndrome brains. Laboratory investigation; a journal of technical methods and pathology, 61 (1). pp. 133-137. ISSN 0023-6837

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Abstract

An immunohistochemical study was carried out on the brains of 12 cases with Down's syndrome (ages 18 to 62) using a monoclonal antibody to amyloid beta-protein with formic acid pretreatment of the sections. Localized ill-defined, weakly immunostained areas with a reticulogranular appearance were the only neocortical lesions observed in two cases aged 31 years. The presence of similar immunoreactive areas with larger size were the predominant cerebral lesions seen in 3 cases who died at the ages of 37 or 38 years. These resembled the "type 3" immunoreactive lesions (lacking any obvious amyloid deposits or abnormal neurites) that were observed previously by us in Alzheimer's disease. In addition to these lesions, older cases of Down's syndrome over 50 years of age showed discrete senile plaques with substantial deposits of amyloid (the number of these lesions increased with age), and many neurofibrillary tangles and cerebrovascular amyloid deposits were also found in these cases. The present observations support the theory that the type 3 lesions are an early stage in senile plaque formation, and suggest that an extensive appearance of type 3 lesions easily detected by immunostaining with formic acid pretreatment is an early neuropathologic change in Alzheimer's disease.

Item Type: Article
Journal or Publication Title: Laboratory investigation; a journal of technical methods and pathology
Uncontrolled Keywords: Adolescent ; Adult ; Amyloid ; Amyloid beta-Peptides ; Brain ; Congo Red ; Down Syndrome ; Humans ; Immunohistochemistry ; Middle Aged ; Silver ; Staining and Labeling
Subjects: UNSPECIFIED
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 50862
Deposited By: ep_importer_pure
Deposited On: 08 Nov 2011 11:28
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 19:44
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/50862

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