Lancaster EPrints

Early senile plaques in Down's syndrome brains show a close relationship with cell bodies of neurons

Allsop, D and Haga, S I and Haga, C and Ikeda, S I and Mann, D M and Ishii, T (1990) Early senile plaques in Down's syndrome brains show a close relationship with cell bodies of neurons. Neuropathology and applied neurobiology, 15 (6). pp. 531-542. ISSN 0305-1846

Full text not available from this repository.

Abstract

A sensitive methenamine silver/Nissl stain was used to study the morphology and relationship of pre-plaques (presumed early senile plaques) in Down's syndrome brains to glial nuclei, capillaries and neuronal perikarya. The larger pre-plaques (greater than 50 microns) usually encompassed all of these tissue elements. However, the smaller pre-plaques (less than or equal to 50 microns) were almost always found immediately adjacent to, or around the cell bodies of neurons (often with associated satellite cells), and they failed to show any consistent, close spatial relationship to the other tissue components. Thus we consider an early stage of pre-plaque formation to be the deposition of amyloid adjacent to the cell body of a morphologically normal neuron. Based on the study of transitional forms, we suggest that the amyloid progressively accumulates around the cell body until the enclosed neuron degenerates. How these pre-plaque lesions might eventually develop into the typical plaque structure is uncertain. Our observations support the theory of a neuronal origin for plaque amyloid.

Item Type: Article
Journal or Publication Title: Neuropathology and applied neurobiology
Uncontrolled Keywords: Adult ; Amyloid ; Amyloid beta-Peptides ; Down Syndrome ; Female ; Humans ; Immunohistochemistry ; Inclusion Bodies ; Male
Subjects: UNSPECIFIED
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 50861
Deposited By: ep_importer_pure
Deposited On: 08 Nov 2011 11:26
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 19:44
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/50861

Actions (login required)

View Item