Ohshima, T and Endo, T and Nukui, H and Ikeda, S and Allsop, D and Onaya, T (1990) Cerebral amyloid angiopathy as a cause of subarachnoid hemorrhage. Stroke; a journal of cerebral circulation, 21 (3). pp. 480-483. ISSN 0039-2499Full text not available from this repository.
Cerebral amyloid angiopathy is a pathologic condition characterized by the deposition of amyloid in the walls of small vessels in the cerebral cortex and meninges. Intracerebral hemorrhage is common in persons with this condition, but pure subarachnoid or subdural hemorrhage is rarely seen. Recently, the existence of two types of amyloid proteins related to cerebral amyloid angiopathy, beta protein and cystatin C, has been reported, and immunohistochemical methods using antisera to these proteins have become available. We describe a patient with fatal subarachnoid hemorrhage presumably caused by beta protein-type cerebral amyloid angiopathy, which was demonstrated immunohistochemically by using a monoclonal antibody to a synthetic peptide corresponding to residues 8-17 of beta protein. We suggest that beta protein-type cerebral amyloid angiopathy is a possible etiologic factor in subarachnoid hemorrhage of unknown cause.
|Journal or Publication Title:||Stroke; a journal of cerebral circulation|
|Uncontrolled Keywords:||Aged ; Amyloidosis ; Brain ; Cerebrovascular Disorders ; Congo Red ; Humans ; Immunohistochemistry ; Male ; Subarachnoid Hemorrhage ; Tomography, X-Ray Computed|
|Departments:||Faculty of Health and Medicine > Biomedical & Life Sciences|
|Deposited On:||08 Nov 2011 11:11|
|Last Modified:||07 Jan 2015 17:00|
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