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Cerebral amyloid angiopathy as a cause of subarachnoid hemorrhage

Ohshima, T and Endo, T and Nukui, H and Ikeda, S and Allsop, D and Onaya, T (1990) Cerebral amyloid angiopathy as a cause of subarachnoid hemorrhage. Stroke; a journal of cerebral circulation, 21 (3). pp. 480-483. ISSN 0039-2499

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Abstract

Cerebral amyloid angiopathy is a pathologic condition characterized by the deposition of amyloid in the walls of small vessels in the cerebral cortex and meninges. Intracerebral hemorrhage is common in persons with this condition, but pure subarachnoid or subdural hemorrhage is rarely seen. Recently, the existence of two types of amyloid proteins related to cerebral amyloid angiopathy, beta protein and cystatin C, has been reported, and immunohistochemical methods using antisera to these proteins have become available. We describe a patient with fatal subarachnoid hemorrhage presumably caused by beta protein-type cerebral amyloid angiopathy, which was demonstrated immunohistochemically by using a monoclonal antibody to a synthetic peptide corresponding to residues 8-17 of beta protein. We suggest that beta protein-type cerebral amyloid angiopathy is a possible etiologic factor in subarachnoid hemorrhage of unknown cause.

Item Type: Article
Journal or Publication Title: Stroke; a journal of cerebral circulation
Uncontrolled Keywords: Aged ; Amyloidosis ; Brain ; Cerebrovascular Disorders ; Congo Red ; Humans ; Immunohistochemistry ; Male ; Subarachnoid Hemorrhage ; Tomography, X-Ray Computed
Subjects:
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 50857
Deposited By: ep_importer_pure
Deposited On: 08 Nov 2011 11:11
Refereed?: Yes
Published?: Published
Last Modified: 17 Sep 2013 08:28
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/50857

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