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The occult aftermath of boxing

Roberts, G W and Allsop, D and Bruton, C (1990) The occult aftermath of boxing. Journal of Neurology Neurosurgery and Psychiatry, 53 (5). pp. 373-378.

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Abstract

The repeated head trauma experienced by boxers can lead to the development of dementia pugilistica (DP)--punch drunk syndrome. The neuropathology of DP in a classic report by Corsellis et al describes the presence of numerous neurofibrillary tangles in the absence of plaques, in contrast to the profusion of tangles and plaques seen in Alzheimer's disease (AD). The DP cases used in that report were re-investigated with immunocytochemical methods and an antibody raised to the beta-protein present in AD plaques. We found that all DP cases with substantial tangle formation showed evidence of extensive beta-protein immunoreactive deposits (plaques). These diffuse "plaques" were not visible with Congo-red or standard silver stains. The degree of beta-protein deposition was comparable to that seen in AD. Our data indicate that the present neuropathological description of DP (tangles but no plaques) should be altered to acknowledge the presence of substantial beta-protein deposition (plaques). The molecular markers present in the plaques and tangles of DP are the same as those in AD. Similarities in clinical symptoms, distribution of pathology and neurochemical deficits also exist. Epidemiological studies have shown that head injury is a risk factor in AD. It is probable that DP and AD share common pathogenic mechanisms leading to tangle and plaque formation.

Item Type: Article
Journal or Publication Title: Journal of Neurology Neurosurgery and Psychiatry
Uncontrolled Keywords: Adult ; Aged ; Aged, 80 and over ; Alzheimer Disease ; Amyloid ; Amyloid beta-Peptides ; Boxing ; Brain ; Brain Concussion ; Brain Damage, Chronic ; Dementia ; Follow-Up Studies ; Humans ; Immunoenzyme Techniques ; Male ; Middle Aged ; Neurofibrils
Subjects: UNSPECIFIED
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 50855
Deposited By: ep_importer_pure
Deposited On: 08 Nov 2011 11:06
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 19:44
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/50855

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