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Quantitative differences in the deposition of βA4 protein in the sulci and gyri of frontal and temporal isocortex in Alzheimer's disease

Gentleman, S M and Allsop, D and Bruton, C J and Jagoe, R and Polak, J M and Roberts, G W (1992) Quantitative differences in the deposition of βA4 protein in the sulci and gyri of frontal and temporal isocortex in Alzheimer's disease. Neuroscience Letters, 136 (1). pp. 27-30. ISSN 0304-3940

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Abstract

The distribution of beta-amyloid protein (beta A4) in the frontal and temporal isocortex of 14 Alzheimer's disease brains was examined using a combination of immunohistochemistry and computer image analysis. The area of cortex covered by beta A4 deposits was determined and expressed as a percentage of the total cortical grey matter area in each field of interest. Significantly more beta A4 was found in the grey matter of the sulci as compared to that of the gyral crests in both the frontal and the temporal lobes (P less than 0.05). Furthermore, in each case, greater quantities of beta A4 were observed in the frontal rather than the temporal lobes. This apparent differential vulnerability is likely to reflect underlying anatomical connections or perhaps differences in cell packing density and appears to strengthen the case for an anatomical basis for the spread of the disease pathology.

Item Type: Article
Journal or Publication Title: Neuroscience Letters
Uncontrolled Keywords: Alzheimer Disease ; Amyloid beta-Peptides ; Frontal Lobe ; Humans ; Neurofibrillary Tangles ; Temporal Lobe
Subjects: UNSPECIFIED
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 50849
Deposited By: ep_importer_pure
Deposited On: 08 Nov 2011 10:23
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 19:44
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/50849

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