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Quantification of βA4 protein deposition in the medial temporal lobe:a comparison of Alzheimer's disease and senile dementia of the Lewy body type

Gentleman, S M and Williams, B and Royston, M C and Jagoe, R and Clinton, J and Perry, R H and Ince, P G and Allsop, D and Polak, J M and Roberts, G W (1992) Quantification of βA4 protein deposition in the medial temporal lobe:a comparison of Alzheimer's disease and senile dementia of the Lewy body type. Neuroscience Letters, 142 (1). pp. 9-12. ISSN 0304-3940

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Abstract

The distribution of beta-amyloid protein (beta A4) was examined in the medial temporal lobes from cases of Alzheimer's disease (AD) (n = 13), senile dementia of Lewy body type (SDLT) (n = 12) and age matched controls (n = 9). Using a previously described image analysis technique the extent of beta A4 pathology was determined in ten distinct anatomical sites within the medial temporal lobe. AD and SDLT cases contained very similar amounts of beta A4 in the areas sampled and both contained significantly more beta A4 than the age matched controls, particularly in the dentate and parahippocampal gyri. The similarity of the beta A4 load in the two conditions is in contrast to reported differences in the number of neurofibrillary tangles which can be observed. It is suggested that AD and SDLT represent a spectrum of pathology which centres around the aberrant processing of the beta A4 precursor protein.

Item Type: Article
Journal or Publication Title: Neuroscience Letters
Uncontrolled Keywords: Aged ; Alzheimer Disease ; Amyloid beta-Peptides ; Dementia ; Female ; Humans ; Lewy Bodies ; Male ; Reference Values ; Temporal Lobe ; Tissue Distribution
Subjects:
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 50848
Deposited By: ep_importer_pure
Deposited On: 08 Nov 2011 10:20
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 19:44
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/50848

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