Clancy, D. J. and Gems, D. and Harshman, L. G. and Oldham, S. and Stocker, H. and Hafen, E. and Leevers, S. J. and Partridge, L. (2001) Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science, 292 (5514). pp. 104-106.
Full text not available from this repository.Abstract
The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. in the nematode Caenorhabditis elegans, insulin/IGF signaling regulates adult longevity. We found that mutation of chico extends fruit fly median Life-span by up to 48% in homozygotes and 36% in heterozygotes. Extension of Life-span was not a result of impaired oogenesis in chico females, nor was it consistently correlated with increased stress resistance. The dwarf phenotype of chico homozygotes was also unnecessary for extension of Life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved.
| Item Type: | Article |
|---|---|
| Journal or Publication Title: | Science |
| Additional Information: | Apr 6 Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein |
| Subjects: | UNSPECIFIED |
| Departments: | Faculty of Health and Medicine > Biomedical & Life Sciences |
| ID Code: | 50161 |
| Deposited By: | ep_importer_pure |
| Deposited On: | 30 Sep 2011 16:49 |
| Refereed?: | Yes |
| Published?: | Published |
| Last Modified: | 26 Jul 2012 19:36 |
| Identification Number: | |
| URI: | http://eprints.lancs.ac.uk/id/eprint/50161 |
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