Broughton, Susan J and Piper, Matthew D W and Ikeya, Tomoatsu and Bass, Timothy M and Jacobson, Jake and Driege, Yasmine and Martinez, Pedro and Hafen, Ernst and Withers, Dominic J and Leevers, Sally J and Partridge, Linda (2005) Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102 (8). pp. 3105-3110. ISSN 0027-8424Full text not available from this repository.
The insulin/insulin-like growth factor-like signaling pathway, present in all multicellular organisms, regulates diverse functions including growth, development, fecundity, metabolic homeostasis, and lifespan. In flies, ligands of the insulin/insulin-like growth factor-like signaling pathway, the Drosophila insulin-like peptides, regulate growth and hemolymph carbohydrate homeostasis during development and are expressed in a stage- and tissue-specific manner. Here, we show that ablation of Drosophila insulin-like peptide-producing median neurosecretory cells in the brain leads to increased fasting glucose levels in the hemolymph of adults similar to that found in diabetic mammals. They also exhibit increased storage of lipid and carbohydrate, reduced fecundity, and reduced tolerance of heat and cold. However, the ablated flies show an extension of median and maximal lifespan and increased resistance to oxidative stress and starvation.
|Journal or Publication Title:||PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA|
|Uncontrolled Keywords:||Ageing ; Carbohydrate Metabolism ; Drosophila ; Insulin ; Lipid Metabolism ; Longevity ; Oxidative Stress ; Starvation|
|Departments:||Faculty of Health and Medicine > Biomedical & Life Sciences|
|Deposited On:||20 Sep 2011 10:28|
|Last Modified:||26 Jul 2012 19:33|
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