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Differentiated regions of human placental cell surface associated with attachment of chorionic villi, phagocytosis of maternal erythrocytes and syncytiotrophoblast repair

Clint, J M and Wakely, J and Ockleford, C D (1979) Differentiated regions of human placental cell surface associated with attachment of chorionic villi, phagocytosis of maternal erythrocytes and syncytiotrophoblast repair. Proceedings of the Royal Society of London. Series B, Containing papers of a Biological character. Royal Society (Great Britain), 204 (1156). pp. 345-353. ISSN 0080-4649

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Abstract

Scanning electron micrographs of human placental cell surface show: (1) Differentiated zones of trophoblast which may be covered by fewer 'microvilli' than the adjacent syncytial cell surface and which extend as a narrow, usually distal protrusion of the chorionic villus. This narrow outgrowth terminates as a fractured end. Presumably since preparations were obtained from therapeutic terminations of pregnancy or Caesarian deliveries these broken ends represent the yield point in the anchoring 'villi' ruptured as a result of surgery. Similar anchoring 'villi' with fractured ends were observed in unfixed material with the use of Nomarski interference contrast microscopy. (2) It appears that, during apparent phagocytic uptake of maternal erythrocytes by syncytiotrophoblast, cell surface lining the forming vacuole still retains an irregular microvillous surface. This observation indicates the potential location of phagocytosis receptors for red blood cells in the placental cell surface. (3) Areas of human placenta which appears to have been damaged and may be undergoing repair exhibit masses of cells with conspicuous microvillar cell surfaces. The origin of these cells is discussed in relation to the usual processes of syncytiotrophoblast formation.

Item Type: Article
Journal or Publication Title: Proceedings of the Royal Society of London. Series B, Containing papers of a Biological character. Royal Society (Great Britain)
Uncontrolled Keywords: Cell Membrane ; Erythrocytes ; Female ; Humans ; Microscopy, Electron, Scanning ; Microvilli ; Phagocytosis ; Placenta ; Pregnancy
Subjects: UNSPECIFIED
Departments: Faculty of Health and Medicine > Medicine
ID Code: 49551
Deposited By: ep_importer_pure
Deposited On: 24 Aug 2011 15:25
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 19:27
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/49551

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