Lancaster EPrints

THE UPTAKE OF IGG BY HUMAN PLACENTAL CHORIONIC VILLI:A CORRELATED AUTORADIOGRAPHIC AND WIDE APERTURE COUNTING STUDY

OCKLEFORD, C D and CLINT, J M (1980) THE UPTAKE OF IGG BY HUMAN PLACENTAL CHORIONIC VILLI:A CORRELATED AUTORADIOGRAPHIC AND WIDE APERTURE COUNTING STUDY. Placenta, 1 (2). pp. 91-111. ISSN 0143-4004

Full text not available from this repository.

Abstract

The uptake of 3H-IgG into human placental chorionic villi in vitro takes place for at least 1 h at 37°C and at 4°C. The rate of uptake is lower at the latter temperature, but still about 20 per cent of the 37°C total. Measurement of cell-associated radioactivity at 4°C cannot therefore be used as a measure of binding: genuine uptake, probably as a result of endocytosis, appears to occur at this temperature. Some proportion of the uptake of IgG at 37°C can be inhibited by colchicine and by cytochalasin B, but some is refractory to these treatments. A coated vesicle-enriched fraction isolated from placenta previously incubated with 3H-IgG was found to be associated with radioisotope.

Item Type: Article
Journal or Publication Title: Placenta
Subjects: UNSPECIFIED
Departments: Faculty of Health and Medicine > Medicine
ID Code: 49312
Deposited By: ep_importer_pure
Deposited On: 29 Jul 2011 14:41
Refereed?: Yes
Published?: Published
Last Modified: 09 Apr 2014 22:40
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/49312

Actions (login required)

View Item