OCKLEFORD, C D and CLINT, J M (1980) THE UPTAKE OF IGG BY HUMAN PLACENTAL CHORIONIC VILLI:A CORRELATED AUTORADIOGRAPHIC AND WIDE APERTURE COUNTING STUDY. Placenta, 1 (2). pp. 91-111. ISSN 0143-4004
Full text not available from this repository.Abstract
The uptake of 3H-IgG into human placental chorionic villi in vitro takes place for at least 1 h at 37°C and at 4°C. The rate of uptake is lower at the latter temperature, but still about 20 per cent of the 37°C total. Measurement of cell-associated radioactivity at 4°C cannot therefore be used as a measure of binding: genuine uptake, probably as a result of endocytosis, appears to occur at this temperature. Some proportion of the uptake of IgG at 37°C can be inhibited by colchicine and by cytochalasin B, but some is refractory to these treatments. A coated vesicle-enriched fraction isolated from placenta previously incubated with 3H-IgG was found to be associated with radioisotope.
| Item Type: | Article |
|---|---|
| Journal or Publication Title: | Placenta |
| Subjects: | UNSPECIFIED |
| Departments: | Faculty of Health and Medicine > Medicine |
| ID Code: | 49312 |
| Deposited By: | ep_importer_pure |
| Deposited On: | 29 Jul 2011 14:41 |
| Refereed?: | Yes |
| Published?: | Published |
| Last Modified: | 26 Jul 2012 19:27 |
| Identification Number: | |
| URI: | http://eprints.lancs.ac.uk/id/eprint/49312 |
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