Liu, Y X and Hu, Z Y and Feng, Q and Gao, H J and Liu, K and Ockleford, C D (2000) Localization and possible role of membrane type metalloproteinase and tissue inhibitors of metalloproteinase-1 in early stages of placentation. Chinese Science Bulletin, 45 (16). pp. 1484-1489. ISSN 1001-6538Full text not available from this repository.
Human placental tissues from the first and second trimesters of gestation have been investigated using riboprobe in situ hybridisation of mRNA sequences coding for membrane type metalloproteinase (MT-1-MMP) and tissue inhibitors of metalloproteinase-l (TIMP-1). Results show that (i) both mRNAs express at a relatively high level in the chorion laeve trophoblast cells and the adjacent decidual cells of fetal membrane; (ii) the most abundant expression of the two mRNAs was found in the extravillous trophoblast between Rohrs and Nitabuch striae of basal plate, trophoblast shell and gland cells of the decidua; (iii) isolated or small groups of cytotrophoblast cells in the chorionic villi and in the cells lining arterioles in decidua and stem villi also expressed both MT-1-MMP and TIMP-1 at defferent extents. The data suggest that the coordinated expression of the MT-MMP and its inhibitor TIMP in defferent cells of the placental tissue may play an essential role in trophoblast invasion and angiogenesis related to placentation in the first two trimesters of gestation. They may also have an ability to effect separation of fetal from material tissue at a favorable junctional site during parturition.
|Journal or Publication Title:||Chinese Science Bulletin|
|Uncontrolled Keywords:||placenta ; trophoblast ; basal plate ; fetal membrane ; MT-1-MMP ; TIMP-1 ; in situ hybridization ; PLASMINOGEN-ACTIVATOR ; MATRIX ; EXPRESSION ; MECHANISMS ; PREGNANCY ; MT1-MMP ; SURFACE ; MMP-2 ; CELLS|
|Departments:||Faculty of Health and Medicine > Medicine|
Faculty of Science and Technology > Mathematics and Statistics
|Deposited On:||24 Aug 2011 10:32|
|Last Modified:||04 Nov 2015 04:02|
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