BRIGHT, N A and OCKLEFORD, C D (1995) CYTOTROPHOBLAST CELLS - A BARRIER TO MATERNOFETAL TRANSMISSION OF PASSIVE-IMMUNITY. Journal of Histochemistry and Cytochemistry, 43 (9). pp. 933-944. ISSN 0022-1554Full text not available from this repository.
The human fetus receives passive immunity via the chorioallantoic placenta in the form of maternal immunoglobulin G (IgG) class antibodies. This provides protection against pathogens at a time when the fetus is immunologically naive. We localized endogenous human IgG using confocal laser scanning fluorescence microscopy and immunoelectron microscopy of frozen sections of chorionic villi from early and late gestation. With confocal microscopy we also investigated the distribution of a receptor for IgG (Fc gamma RIII; CD16) that is typically expressed on the surface of human leukocytes. Endogenous IgG was present in the syncytiotrophoblast that surrounds chorionic villi but underlying cytotrophoblast cells were devoid of endogenous antibody. Fc gamma RIII immunoreactivity was confined to the syncytiotrophoblast and was also absent from cytotrophoblast cells. We propose that cytotrophoblast cells represent a barrier to the transmission of maternally derived IgG across the human placenta. This accounts for the paradox that there are low levels of transport in the first trimester when the syncytiotrophoblast is known to express receptors for IgG. Cytotrophoblast cells form an almost complete epithelial layer underlying the syncytiotrophoblast at this stage of gestation, but this becomes discontinuous as the placenta matures, thus removing the cellular impediment to IgG transmission.
|Journal or Publication Title:||Journal of Histochemistry and Cytochemistry|
|Uncontrolled Keywords:||HUMAN PLACENTA ; CYTOTROPHOBLAST CELLS ; IMMUNOGLOBULIN G ; IMMUNOCYTOCHEMISTRY ; IMMUNOELECTRON MICROSCOPY ; FC RECEPTORS ; PASSIVE IMMUNITY ; ULTRATHIN FROZEN-SECTIONS ; HUMAN-PLACENTA ; IMMUNOGLOBULIN-G ; IGG SUBCLASSES ; LOCALIZATION ; RECEPTORS|
|Departments:||Faculty of Health and Medicine > Medicine|
|Deposited On:||05 Aug 2011 00:24|
|Last Modified:||07 Jan 2015 16:49|
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