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Leishmania sand fly interaction:progress and challenges

Bates, Paul A (2008) Leishmania sand fly interaction:progress and challenges. Current Opinion in Microbiology, 11 (4). pp. 340-344. ISSN 1369-5274

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Abstract

Complex interactions occurs between Leishmania parasites and their sand fly vectors. Promastigotes of Leishmania live exclusively within the gut, possess flagella and are motile, and kinesins, kinases and G proteins have been described that play a role in regulating flagellar assembly. Movement within the gut is not random: promastigotes can detect gradients of solutes via chemotaxis and osmotaxis. Further they use their flagella to attach to the fly midgut using surface glyconconjugates, a key step in establishment of the infection. Differentiation of mammal-infective stages is characterised by significant biochemical and cellular remodelling. Further, the parasites can manipulate the behaviour of the vector to maximise their transmission, and flies may even deliver altruistic apoptotic forms to aid transmission of infective stages.

Item Type: Article
Journal or Publication Title: Current Opinion in Microbiology
Uncontrolled Keywords: Animals ; Cell Adhesion ; Disease Vectors ; Gastrointestinal Tract ; Leishmania ; Locomotion ; Psychodidae
Subjects: Q Science > QR Microbiology > QR355 Virology
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 49226
Deposited By: ep_importer_pure
Deposited On: 27 Jul 2011 13:54
Refereed?: Yes
Published?: Published
Last Modified: 06 Aug 2012 09:06
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/49226

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