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Sutureless amniotic membrane transplantation for ocular surface reconstruction with a chemically defined bioadhesive

Takaoka, Maho and Nakamura, Takahiro and Sugai, Hajime and Bentley, Adam James and Nakajima, Naoki and Fullwood, Nigel J. and Yokoi, Norihiko and Hyon, Suong-Hyu and Kinoshita, Shigeru (2008) Sutureless amniotic membrane transplantation for ocular surface reconstruction with a chemically defined bioadhesive. Biomaterials, 29 (19). pp. 2923-2931. ISSN 0142-9612

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Abstract

The purpose of this study was to evaluate the efficiency and safety of a sutureless amniotic membrane transplantation (AMT) for ocular surface reconstruction with a chemically defined bioadhesive (CDB). The CDB was synthesized from aldehyded polysaccharides and epsilon-poly(L-lysine), two kinds of medical and food additives, as starting materials. Biocompatibility assay indicated that the CDB showed excellent biocompatibility with in vitro and in vivo ocular surface tissues and most of the CDB was histologically degraded within 4 weeks. Sutureless AMT using the CDB was safely and successfully performed onto a rabbit scleral surface. Transplanted amniotic membrane (AM) evaluated by histological, electron microscopic- and immunohistochemical examination indicated that the CDB did not affect normal differentiation of the cells or the integrity of the surrounding tissue. Thus, this newly developed CDB was found to be very useful for sutureless AMT for ocular surface reconstruction, without considering the risk of infection. It has the ability to fix AM to the ocular surface for a long time-period without additional inflammation, scarring, or damage to the surrounding tissues. (C) 2008 Elsevier Ltd. All rights reserved.

Item Type: Article
Journal or Publication Title: Biomaterials
Uncontrolled Keywords: ophthalmology ; transplantation ; sutureless ; ocular surface ; bioadhesive ; biocompatibility ; SEALING CORNEAL INCISIONS ; STEM-CELL TRANSPLANTATION ; PARVOVIRUS B19 INFECTION ; STEVENS-JOHNSON-SYNDROME ; LIMBAL EPITHELIAL-CELLS ; TISSUE ADHESIVE ; FIBRIN GLUE ; AUTOLOGOUS TRANSPLANTATION ; CONJUNCTIVAL AUTOGRAFTS ; RECURRENT PTERYGIA
Subjects: UNSPECIFIED
Departments: Faculty of Science and Technology > Lancaster Environment Centre
Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 49179
Deposited By: ep_importer_pure
Deposited On: 24 Aug 2011 09:17
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 19:25
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/49179

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