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Hes1 regulates corneal development and the function of corneal epithelial stem/progenitor cells

Nakamura, Takahiro and Ohtsuka, Toshiyuki and Sekiyama, Eiichi and Cooper, Leanne J. and Kokubu, Hiroshi and Fullwood, Nigel J. and Barrandon, Yann and Kageyama, Ryoichiro and Kinoshita, Shigeru (2008) Hes1 regulates corneal development and the function of corneal epithelial stem/progenitor cells. Stem Cells, 26 (5). pp. 1265-1274. ISSN 1066-5099

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Abstract

Hes1, a major target gene in Notch signaling, regulates the fate and differentiation of various cell types in many developmental systems. To gain a novel insight into the role of Hes1 in corneal tissue, we performed gain-of-function and loss-of-function studies. We show that corneal development was severely disturbed in Hes1-null mice. Hes1-null corneas manifested abnormal junctional specialization, cell differentiation, and less cell proliferation ability. Worthy of note, Hes1 is expressed mainly in the corneal epithelial stem/progenitor cells and is not detected in the differentiated corneal epithelial cells. Expression of Hes1 is closely linked with corneal epithelial stem/progenitor cell proliferation activity in vivo. Moreover, forced Hes1 expression inhibits the differentiation of corneal epithelial stem/progenitor cells and maintains these cells' undifferentiated state. Our data provide the first evidence that Hes1 regulates corneal development and the homeostatic function of corneal epithelial stem/progenitor cells.

Item Type: Article
Journal or Publication Title: Stem Cells
Uncontrolled Keywords: cornea ; development ; Hes ; Notch ; stem cell ; CENTRAL-NERVOUS-SYSTEM ; HELIX FACTOR HES-1 ; NEURAL STEM-CELLS ; TRANSCRIPTION FACTOR ; MAMMALIAN HAIRY ; NOTCH ; DIFFERENTIATION ; P63 ; EXPRESSION ; ENHANCER
Subjects:
Departments: Faculty of Science and Technology > Lancaster Environment Centre
Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 49177
Deposited By: ep_importer_pure
Deposited On: 24 Aug 2011 09:12
Refereed?: Yes
Published?: Published
Last Modified: 06 Nov 2014 08:54
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/49177

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