Tabner, Brian and Turnbull, Stuart and Fullwood, N J and German, Matthew and Allsop, D (2005) The production of hydrogen peroxide during early-stage protein aggregation: a common pathological mechanism in different neurodegenerative diseases? Biochemical Society Transactions, 33 (4). pp. 548-550. ISSN 0300-5127Full text not available from this repository.
By means of an ESR spin-trapping method, we have shown that A beta (amyloid beta), alpha-synuclein and various toxic forms of the prion protein all appear to generate H2O2 in vitro. A fundamental molecular mechanism underlying the pathogenesis of cell death in several different neurodegenerative diseases could be the direct production of H2O2 during the early stages of protein aggregation.
|Journal or Publication Title:||Biochemical Society Transactions|
|Uncontrolled Keywords:||Alzheimer's disease ; H2O2 ; neuradegeneration ; Parkinson's disease ; prion ; protein aggregation ; PARKINSONS-DISEASE ; ALZHEIMERS-DISEASE ; ALPHA-SYNUCLEIN ; A-BETA ; PEPTIDE ; GENERATION ; OLIGOMERS ; RADICALS|
|Subjects:||Q Science > QH Natural history > QH301 Biology|
|Departments:||Faculty of Science and Technology > Lancaster Environment Centre|
Faculty of Health and Medicine > Biomedical & Life Sciences
|Deposited On:||05 Sep 2011 14:35|
|Last Modified:||26 Jul 2012 19:25|
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