Tabner, Brian and Turnbull, Stuart and Fullwood, N J and German, Matthew and Allsop, D (2005) The production of hydrogen peroxide during early-stage protein aggregation: a common pathological mechanism in different neurodegenerative diseases? Biochemical Society Transactions, 33 (4). pp. 548-550. ISSN 0300-5127
Full text not available from this repository.Abstract
By means of an ESR spin-trapping method, we have shown that A beta (amyloid beta), alpha-synuclein and various toxic forms of the prion protein all appear to generate H2O2 in vitro. A fundamental molecular mechanism underlying the pathogenesis of cell death in several different neurodegenerative diseases could be the direct production of H2O2 during the early stages of protein aggregation.
| Item Type: | Article |
|---|---|
| Journal or Publication Title: | Biochemical Society Transactions |
| Uncontrolled Keywords: | Alzheimer's disease ; H2O2 ; neuradegeneration ; Parkinson's disease ; prion ; protein aggregation ; PARKINSONS-DISEASE ; ALZHEIMERS-DISEASE ; ALPHA-SYNUCLEIN ; A-BETA ; PEPTIDE ; GENERATION ; OLIGOMERS ; RADICALS |
| Subjects: | Q Science > QH Natural history > QH301 Biology |
| Departments: | Faculty of Science and Technology > Lancaster Environment Centre Faculty of Health and Medicine > Biomedical & Life Sciences |
| ID Code: | 49164 |
| Deposited By: | ep_importer_pure |
| Deposited On: | 05 Sep 2011 14:35 |
| Refereed?: | Yes |
| Published?: | Published |
| Last Modified: | 26 Jul 2012 19:25 |
| Identification Number: | |
| URI: | http://eprints.lancs.ac.uk/id/eprint/49164 |
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