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The production of hydrogen peroxide during early-stage protein aggregation: a common pathological mechanism in different neurodegenerative diseases?

Tabner, Brian and Turnbull, Stuart and Fullwood, N J and German, Matthew and Allsop, D (2005) The production of hydrogen peroxide during early-stage protein aggregation: a common pathological mechanism in different neurodegenerative diseases? Biochemical Society Transactions, 33 (4). pp. 548-550. ISSN 0300-5127

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Abstract

By means of an ESR spin-trapping method, we have shown that A beta (amyloid beta), alpha-synuclein and various toxic forms of the prion protein all appear to generate H2O2 in vitro. A fundamental molecular mechanism underlying the pathogenesis of cell death in several different neurodegenerative diseases could be the direct production of H2O2 during the early stages of protein aggregation.

Item Type: Article
Journal or Publication Title: Biochemical Society Transactions
Uncontrolled Keywords: Alzheimer's disease ; H2O2 ; neuradegeneration ; Parkinson's disease ; prion ; protein aggregation ; PARKINSONS-DISEASE ; ALZHEIMERS-DISEASE ; ALPHA-SYNUCLEIN ; A-BETA ; PEPTIDE ; GENERATION ; OLIGOMERS ; RADICALS
Subjects: Q Science > QH Natural history > QH301 Biology
Departments: Faculty of Science and Technology > Lancaster Environment Centre
Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 49164
Deposited By: ep_importer_pure
Deposited On: 05 Sep 2011 14:35
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 19:25
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/49164

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