Fullwood, Nigel J. and Martin, Frank and Bentley, Adam and Lee, Jin Pyung and Lee, Sang Joon (2011) Imaging sclera with hard X-ray microscopy. Micron, 42 (5). pp. 506-511. ISSN 0968-4328Full text not available from this repository.
In this study, the organization of collagen fibrils within the sclera of the eye was investigated using the 7 keV hard X-ray microscope of the Pohang light source and compared to images from electron and atomic force microscopy. From the captured X-ray images, individual collagen fibrils were observed clearly in a spatial resolution much better than 100 nm, both in longitudinal sections and in transverse sections. Some of the collagen fibrils showed evidence of axial periodicity. In some regions of the samples, we could see cross-bridge like structures between adjacent collagen fibrils. The X-ray microscope also allowed the observation of keratocytes and the lamella structure of the scleral stroma. The X-ray microscope has some unique advantages in the nano-scale imaging of bio-samples relative to other established imaging techniques. (C) 2011 Elsevier Ltd. All rights reserved.
|Journal or Publication Title:||Micron|
|Uncontrolled Keywords:||X-ray microscopy ; Synchrotron ; Sclera ; Collagen ; Proteoglycans ; OBSERVING TRANSPARENT SPECIMENS ; PHASE-CONTRAST ; ELECTRON-MICROSCOPY ; CORNEAL STROMA ; RESOLUTION ; COLLAGENS ; AGGRECAN|
|Departments:||Faculty of Health and Medicine > Biomedical & Life Sciences|
Faculty of Science and Technology > Lancaster Environment Centre
|Deposited On:||21 Jul 2011 16:32|
|Last Modified:||26 Jul 2012 19:23|
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