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Cannabinoid CB2 receptors in the gastrointestinal tract : a regulatory system in states of inflammation.

Wright, K. L. and Duncan, M. and Sharkey, K. A. (2008) Cannabinoid CB2 receptors in the gastrointestinal tract : a regulatory system in states of inflammation. British Journal of Pharmacology, 153 (2). pp. 263-270. ISSN 1476-5381

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Abstract

The emerging potential for the cannabinoid (CB) system in modulating gastrointestinal inflammation has gained momentum over the last few years. Traditional and anecdotal use of marijuana for gastrointestinal disorders, such as diarrhoea and abdominal cramps is recognized, but the therapeutic benefit of cannabinoids in the 21st century is overshadowed by the psychoactive problems associated with CB1 receptor activation. However, the presence and function of the CB2 receptor in the GI tract, whilst not yet well characterized, holds great promise due to its immunomodulatory roles in inflammatory systems and its lack of psychotropic effects. This review of our current knowledge of CB2 receptors in the gastrointestinal tract highlights its role in regulating abnormal motility, modulating intestinal inflammation and limiting visceral sensitivity and pain. CB2 receptors represent a braking system and a pathophysiological mechanism for the resolution of inflammation and many of its symptoms. CB2 receptor activation therefore represents a very promising therapeutic target in gastrointestinal inflammatory states where there is immune activation and motility dysfunction.

Item Type: Article
Journal or Publication Title: British Journal of Pharmacology
Uncontrolled Keywords: inflammatory bowel disease ; colitis ; cannabis ; endocannabinoids ; enteric nervous system ; gastrointestinal motility ; bowel cancer ; visceral sensation
Subjects: R Medicine > RM Therapeutics. Pharmacology
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 40886
Deposited By: Mr Richard Ingham
Deposited On: 16 Jun 2011 09:35
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 18:06
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/40886

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