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Cellular and sub-cellular responses to UVA in relation to carcinogenesis

Ridley, Andrew J. and Whiteside, James R. and McMillan, Trevor J. and Allinson, Sarah L. (2009) Cellular and sub-cellular responses to UVA in relation to carcinogenesis. International Journal of Radiation Biology, 85 (3). pp. 177-195. ISSN 1362-3095

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Abstract

PURPOSE: UVA radiation (315-400 nm) contributes to skin aging and carcinogenesis. The aim of this review is to consider the mechanisms that underlie UVA-induced cellular damage, how this damage may be prevented or repaired and the signal transduction processes that are elicited in response to it. RESULTS: Exposure to ultraviolet (UV) light is well-established as the causative factor in skin cancer. Until recently, most work on the mechanisms that underlie skin carcinogenesis focused on shorter wavelength UVB radiation (280-315 nm), however in recent years there has been increased interest in the contribution made by UVA. UVA is able to cause a range of damage to cellular biomolecules including lipid peroxidation, oxidized protein and DNA damage, such as 8-oxoguanine and cyclobutane pyrimidine dimers. Such damage is strongly implicated in both cell death and malignant transformation and cells have a number of mechanisms in place to mitigate the effects of UVA exposure, including antioxidants, DNA repair, and stress signalling pathways. CONCLUSIONS: The past decade has seen a surge of interest in the biological effects of UVA exposure as its significance to the process of photo-carcinogenesis has become increasingly evident. However, unpicking the unique complexity of the cellular response to UVA, which is only now becoming apparent, will be a major challenge for the field of photobiology in the 21st century

Item Type: Article
Journal or Publication Title: International Journal of Radiation Biology
Uncontrolled Keywords: UVA ; antioxidants ; reactive oxygen species ; base excision repair ; ATM ; MAPK ; p53
Subjects: R Medicine > RL Dermatology
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
Faculty of Science and Technology > Lancaster Environment Centre
VC's Office
ID Code: 40737
Deposited By: Professor Trevor McMillan
Deposited On: 28 Apr 2011 09:02
Refereed?: Yes
Published?: Published
Last Modified: 01 Nov 2012 15:17
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/40737

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