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Moonlighting enzymes in parasitic protozoa.

Collingridge, Peter W. and Brown, Robert W. B. and Ginger, Michael L. (2010) Moonlighting enzymes in parasitic protozoa. Parasitology, 137 (9). pp. 1467-1475. ISSN 0031-1820

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Abstract

Enzymes moonlight in a non-enzymatic capacity in a diverse variety of cellular processes. The discovery of these non-enzymatic functions is generally unexpected, and moonlighting enzymes are known in both prokaryotes and eukaryotes. Importantly, this unexpected multi-functionality indicates that caution might be needed on some occasions in interpreting phenotypes that result from the deletion or gene-silencing of some enzymes, including some of the best known enzymes from classic intermediary metabolism. Here, we provide an overview of enzyme moonlighting in parasitic protists. Unequivocal and putative examples of moonlighting are discussed, together with the possibility that the unusual biological characteristics of some parasites either limit opportunities for moonlighting to arise or perhaps contribute to the evolution of novel proteins with clear metabolic ancestry.

Item Type: Article
Journal or Publication Title: Parasitology
Additional Information: http://journals.cambridge.org/action/displayJournal?jid=PAR The final, definitive version of this article has been published in the Journal, Parasitology, 137 (9), pp 1467-1475 2010, © 2010 Cambridge University Press.
Subjects: Q Science > QH Natural history > QH301 Biology
Departments: Faculty of Health and Medicine > Biomedical & Life Sciences
ID Code: 34899
Deposited By: Dr Michael Ginger
Deposited On: 14 Dec 2010 15:01
Refereed?: Yes
Published?: Published
Last Modified: 26 Jul 2012 17:43
Identification Number:
URI: http://eprints.lancs.ac.uk/id/eprint/34899

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