Collingridge, Peter W. and Brown, Robert W. B. and Ginger, Michael L. (2010) Moonlighting enzymes in parasitic protozoa. Parasitology, 137 (9). pp. 1467-1475. ISSN 0031-1820Full text not available from this repository.
Enzymes moonlight in a non-enzymatic capacity in a diverse variety of cellular processes. The discovery of these non-enzymatic functions is generally unexpected, and moonlighting enzymes are known in both prokaryotes and eukaryotes. Importantly, this unexpected multi-functionality indicates that caution might be needed on some occasions in interpreting phenotypes that result from the deletion or gene-silencing of some enzymes, including some of the best known enzymes from classic intermediary metabolism. Here, we provide an overview of enzyme moonlighting in parasitic protists. Unequivocal and putative examples of moonlighting are discussed, together with the possibility that the unusual biological characteristics of some parasites either limit opportunities for moonlighting to arise or perhaps contribute to the evolution of novel proteins with clear metabolic ancestry.
|Journal or Publication Title:||Parasitology|
|Additional Information:||http://journals.cambridge.org/action/displayJournal?jid=PAR The final, definitive version of this article has been published in the Journal, Parasitology, 137 (9), pp 1467-1475 2010, © 2010 Cambridge University Press.|
|Subjects:||Q Science > QH Natural history > QH301 Biology|
|Departments:||Faculty of Health and Medicine > Biomedical & Life Sciences|
|Deposited By:||Dr Michael Ginger|
|Deposited On:||14 Dec 2010 15:01|
|Last Modified:||05 Feb 2016 01:41|
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